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UniProtKB/Swiss-Prot entry Q8K4D8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL1A3_RAT
Primary accession number Q8K4D8
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 43)
Name and origin of the protein
Protein name Aldehyde dehydrogenase family 1 member A3
Synonyms EC 1.2.1.5
Aldehyde dehydrogenase 6
Retinaldehyde dehydrogenase 3
RALDH-3
Gene name
Name: Aldh1a3
Synonyms: Aldh6, Raldh3
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
DOI=10.1095/biolreprod.102.007021; PubMed=12390888 [NCBI, ExPASy, EBI, Israel, Japan]
Rexer B.N., Ong D.E.;
"A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium.";
Biol. Reprod. 67:1555-1564(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF434845; AAN03711.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_695212.1; -.
UniGene Rn.213725
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase Q8K4D8.
Organism-specific databases
RGD 628662; Aldh1a3.
Gene expression databases
ArrayExpress Q8K4D8; -.
GermOnline ENSRNOG00000013028; Rattus norvegicus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004030; Molecular function: aldehyde dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
Genome annotation databases
Ensembl ENSRNOG00000013028; Rattus norvegicus. [Contig view]
GeneID 266603; -.
KEGG rno:266603; -.
Phylogenomic databases
HOVERGEN Q8K4D8; -.
Other
NextBio 624416; -.
ProtoNet Q8K4D8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   512  512     Aldehyde dehydrogenase family 1 member A3. PRO_0000056480
NP_BIND   257   262  6     NAD (By similarity). 
ACT_SITE   280   280        Proton acceptor (By similarity). 
ACT_SITE   314   314        Nucleophile (By similarity). 
SITE   181   181  1     Transition state stabilizer (By similarity). 
Sequence information
Length: 512 AA [This is the length of the unprocessed precursor] Molecular weight: 56171 Da [This is the MW of the unprocessed precursor] CRC64: 2A818D7472F67A5E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATANGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HEPKSGRKFA TYNPSTLEKI 

        70         80         90        100        110        120 
CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL HQLADLIERD RAILATLETM 

       130        140        150        160        170        180 
DTGKPFLHAF FVDLEGCIKT FRYFAGWADK IQGRTIPTDD NVMCFTRHEP IGVCGAITPW 

       190        200        210        220        230        240 
NFPLLMLAWK LAPALCCGNT VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV 

       250        260        270        280        290        300 
GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGRNPCIVC ADADLDLAVE 

       310        320        330        340        350        360 
CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK TEQGPQIDQK 

       370        380        390        400        410        420 
QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD VTDNMRIAKE EIFGPVQPIL 

       430        440        450        460        470        480 
KFKNLEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWVNCYNA FYAQAPFGGF 

       490        500        510 
KMSGNGRELG EYALAEYTEV KTVTIKLDEK NP
Q8K4D8 in FASTA format

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