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UniProtKB/Swiss-Prot entry Q8K2D6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DCTD_MOUSE
Primary accession number Q8K2D6
Secondary accession number Q8BP55
Integrated into Swiss-Prot on March 29, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name Deoxycytidylate deaminase
Synonyms EC 3.5.4.12
dCMP deaminase
Gene name
Name: Dctd
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Hypothalamus, and Testis;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK031645; BAC27492.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK039066; BAC30229.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK077663; BAC36937.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC031719; AAH31719.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_848903.1; -.
UniGene Mm.121549
3D structure databases
ModBase Q8K2D6.
PTM databases
PhosphoSite Q8K2D6; -.
Organism-specific databases
MGI MGI:2444529; Dctd.
Gene expression databases
ArrayExpress Q8K2D6; -.
CleanEx MM_DCTD; -.
Ontologies
GO
GO:0004132; Molecular function: dCMP deaminase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0009165; Biological process: nucleotide biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016192; APOBEC/CMP_deaminase_Zn-bd.
IPR002125; CMP_dCMP_Zn_bd.
IPR015517; Cyt_deaminase.
IPR016473; dCMP_deaminase.
Graphical view of domain structure.
PANTHER PTHR11086; Cyt_deaminase; 1.
Pfam PF00383; dCMP_cyt_deam_1; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF006019; dCMP_deaminase; 1.
PROSITE PS00903; CYT_DCMP_DEAMINASES; 1.
Genome annotation databases
Ensembl ENSMUSG00000031562; Mus musculus. [Contig view]
GeneID 320685; -.
KEGG mmu:320685; -.
Phylogenomic databases
HOGENOM Q8K2D6; -.
HOVERGEN Q8K2D6; -.
Other
NextBio 397213; -.
SOURCE Dctd; Mus musculus.
ProtoNet Q8K2D6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Allosteric enzyme; Hydrolase; Metal-binding; Nucleotide biosynthesis; Phosphoprotein; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   178  178     Deoxycytidylate deaminase. PRO_0000171692
ACT_SITE   86    86        Proton donor (By similarity). 
METAL   84    84        Zinc; catalytic (By similarity). 
METAL   110   110        Zinc; catalytic (By similarity). 
METAL   113   113        Zinc; catalytic (By similarity). 
MOD_RES   79    79        Phosphotyrosine (By similarity). 
CONFLICT   35    35        S -> F (in Ref. 1; BAC36937). 
Sequence information
Length: 178 AA [This is the length of the unprocessed precursor] Molecular weight: 20059 Da [This is the MW of the unprocessed precursor] CRC64: A53ED5C676965029 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG IGYNGMPNGC 

        70         80         90        100        110        120 
SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG CSMYVALFPC NECAKLIIQA 

       130        140        150        160        170 
GIKEVIFMSD KYHDSEETTA ARLLFKLAGV TFRKFTPKYS KIVIDFDSIN SRPSQKPQ 

Q8K2D6 in FASTA format

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