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UniProtKB/Swiss-Prot entry Q8K009

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL1L2_MOUSE
Primary accession number Q8K009
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 48)
Name and origin of the protein
Protein name Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2
Synonyms EC 1.5.1.6
Aldehyde dehydrogenase family 1 member L2
Gene name
Name: Aldh1l2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Salivary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC034531; AAH34531.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_705771.1; -.
UniGene Mm.263138
3D structure databases
HSSP P28037; 1S3I. [HSSP ENTRY / PDB]
SMR Q8K009; 426-923.
ModBase Q8K009.
PTM databases
PhosphoSite Q8K009; -.
Organism-specific databases
MGI MGI:2444680; Aldh1l2.
Gene expression databases
ArrayExpress Q8K009; -.
CleanEx MM_ALDH1L2; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0000036; Molecular function: acyl carrier activity (inferred from electronic annotation from InterPro).
GO:0048037; Molecular function: cofactor binding (inferred from electronic annotation from InterPro).
GO:0016155; Molecular function: formyltetrahydrofolate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0016742; Molecular function: hydroxymethyl-, formyl- and related transferase activity (inferred from electronic annotation from InterPro).
GO:0031177; Molecular function: phosphopantetheine binding (inferred from electronic annotation from InterPro).
GO:0009258; Biological process: 10-formyltetrahydrofolate catabolic process (inferred from electronic annotation from InterPro).
GO:0009058; Biological process: biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011407; 10_FTHF_DHase.
IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005793; Formyl_trans_C.
IPR002376; Formyl_transf_N.
IPR001555; GART_AS.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
G3DSA:3.10.25.10; Formyl_trans_C; 1.
G3DSA:3.40.50.170; Formyl_transf_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
PF02911; Formyl_trans_C; 1.
PF00551; Formyl_trans_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036489; 10-FTHFDH; 1.
PROSITE PS50075; ACP_DOMAIN; 1.
PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PS00373; GART; 1.
PS00012; PHOSPHOPANTETHEINE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8K009; -.
Genome annotation databases
Ensembl ENSMUSG00000020256; Mus musculus. [Contig view]
GeneID 216188; -.
KEGG mmu:216188; -.
Phylogenomic databases
HOGENOM Q8K009; -.
HOVERGEN Q8K009; -.
Other
NextBio 375062; -.
SOURCE Aldh1l2; Mus musculus.
ProtoNet Q8K009.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NADP; One-carbon metabolism; Oxidoreductase; Phosphopantetheine.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   923  923     Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2. PRO_0000316002
DOMAIN   344   413  70     Acyl carrier. 
REGION   23   225  203     GART. 
REGION   438   923  486     Aldehyde dehydrogenase. 
ACT_SITE   128   128        Proton donor (By similarity). 
ACT_SITE   694   694        By similarity. 
ACT_SITE   728   728        By similarity. 
BINDING   375   375        Phosphopantetheine (covalent) (By similarity). 
SITE   164   164  1     Essential for catalytic activity (By similarity). 
Sequence information
Length: 923 AA [This is the length of the unprocessed precursor] Molecular weight: 101564 Da [This is the MW of the unprocessed precursor] CRC64: 441D57CAF3D11303 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG VFTVPDKDGK 

        70         80         90        100        110        120 
ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA ELNVLPFCTQ FIPMDVIDSP 

       130        140        150        160        170        180 
KHGSIIYHPS LLPRHRGASA INWTLIMGDK KAGFSVFWAD DGLDTGPILL QRSCDVKPND 

       190        200        210        220        230        240 
TVDSLYNRFL FPEGIKAMVE AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE 

       250        260        270        280        290        300 
GLHNWIRGHD KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL 

       310        320        330        340        350        360 
FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV IWARILSNTP 

       370        380        390        400        410        420 
VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY MATKFGDFIQ KVVRRLRGED 

       430        440        450        460        470        480 
EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ FVDAEDGETY ATVNPTDGTT ICRVSHASLA 

       490        500        510        520        530        540 
DVDRAVAAAK DAFENGEWGR MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL 

       550        560        570        580        590        600 
KTHIGMSVQT FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM 

       610        620        630        640        650        660 
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS GGVAGQRLSQ 

       670        680        690        700        710        720 
HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP LIIFSDCDLE KAVRMGMGAV 

       730        740        750        760        770        780 
FFNKGENCIA AGRLFVEEAI HDEFVTRVVE EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL 

       790        800        810        820        830        840 
QYCETGVQEG ATLVYGGRQV QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD 

       850        860        870        880        890        900 
IDGVLQRANN TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG 

       910        920 
FGKDLGEEAL NEYLKIKTVT LEY
Q8K009 in FASTA format

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