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UniProtKB/Swiss-Prot entry Q8JZV9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BDH2_MOUSE
Primary accession number Q8JZV9
Secondary accession numbers None
Integrated into Swiss-Prot on October 11, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 47)
Name and origin of the protein
Protein name 3-hydroxybutyrate dehydrogenase type 2
Synonyms EC 1.1.1.30
R-beta-hydroxybutyrate dehydrogenase
Dehydrogenase/reductase SDR family member 6
Gene name
Name: Bdh2
Synonyms: Dhrs6
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC036998; AAH36998.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_081484.1; -.
UniGene Mm.45121
3D structure databases
HSSP P97852; 1GZ6. [HSSP ENTRY / PDB]
SMR Q8JZV9; 1-245.
ModBase Q8JZV9.
PTM databases
PhosphoSite Q8JZV9; -.
Organism-specific databases
MGI MGI:1917022; Bdh2.
Gene expression databases
ArrayExpress Q8JZV9; -.
CleanEx MM_BDH2; -.
GermOnline ENSMUSG00000028167; Mus musculus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from HGNC).
GO:0003858; Molecular function: 3-hydroxybutyrate dehydrogenase activity (inferred from sequence or structural similarity from HGNC).
GO:0051287; Molecular function: NAD binding (inferred from sequence or structural similarity from HGNC).
GO:0006635; Biological process: fatty acid beta-oxidation (inferred from sequence or structural similarity from HGNC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
Genome annotation databases
Ensembl ENSMUSG00000028167; Mus musculus. [Contig view]
GeneID 69772; -.
KEGG mmu:69772; -.
NMPDR fig|10090.3.peg.9033; -.
Phylogenomic databases
HOVERGEN Q8JZV9; -.
Other
NextBio 330302; -.
SOURCE Bdh2; Mus musculus.
ProtoNet Q8JZV9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   245  245     3-hydroxybutyrate dehydrogenase type 2. PRO_0000042581
NP_BIND   10    37  28     NAD (By similarity). 
NP_BIND   180   184  5     NAD (By similarity). 
ACT_SITE   147   147        Proton acceptor (By similarity). 
BINDING   58    58        NAD (By similarity). 
BINDING   144   144        Substrate (By similarity). 
BINDING   151   151        NAD (By similarity). 
BINDING   188   188        Substrate (By similarity). 
BINDING   205   205        Substrate (By similarity). 
MOD_RES   132   132        Phosphoserine (By similarity). 
Sequence information
Length: 245 AA [This is the length of the unprocessed precursor] Molecular weight: 26753 Da [This is the MW of the unprocessed precursor] CRC64: 343A25B1F56B9CCF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGRLDGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE SKLQELESYR GIQTRVLDVT 

        70         80         90        100        110        120 
KKRQIDQFAS EIERIDVLFN VAGFVHHGTI LDCEEKDWDF SMNLNVRSMF LMIKAFLPKM 

       130        140        150        160        170        180 
LAQKSGNIIN MSSVASSIKG VENRCVYSAT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 

       190        200        210        220        230        240 
DTPSLQERIQ ARDNPKEALK TFLNRQKTGR FASAEEVALL CVYLASDESA YVTGNPVIID 


GGWSL
Q8JZV9 in FASTA format

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