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UniProtKB/Swiss-Prot entry Q8JH71

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDOB_DANRE
Primary accession number Q8JH71
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name Fructose-bisphosphate aldolase B
Synonyms EC 4.1.2.13
Liver-type aldolase
Gene name
Name: aldob
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/s00239-002-2363-8; PubMed=12486526 [NCBI, ExPASy, EBI, Israel, Japan]
Merritt T.J.S., Quattro J.M.;
"Negative charge correlates with neural expression in vertebrate aldolase isozymes.";
J. Mol. Evol. 55:674-683(2002).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney marrow;
DOI=10.1073/pnas.0407241101; PubMed=15520368 [NCBI, ExPASy, EBI, Israel, Japan]
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.;
"Hematopoietic gene expression profile in zebrafish kidney marrow.";
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF533646; AAN04477.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY394965; AAQ94592.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC062830; AAH62830.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_919348.3; -.
UniGene Dr.76309
3D structure databases
HSSP P05062; 1QO5. [HSSP ENTRY / PDB]
SMR Q8JH71; 3-364.
ModBase Q8JH71.
Organism-specific databases
ZFIN ZDB-GENE-030131-383; aldob.
Gene expression databases
ArrayExpress Q8JH71; -.
Ontologies
GO
GO:0004332; Molecular function: fructose-bisphosphate aldolase activity (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000741; Aldolase_I.
IPR013785; Aldolase_TIM.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR11627; Aldolase_I; 1.
Pfam PF00274; Glycolytic; 1.
Pfam graphical view of domain structure.
ProDom PD001128; Aldolase_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00158; ALDOLASE_CLASS_I; 1.
Genome annotation databases
Ensembl ENSDARG00000053684; Danio rerio. [Contig view]
GeneID 321664; -.
KEGG dre:321664; -.
Phylogenomic databases
HOVERGEN Q8JH71; -.
Other
ProtoNet Q8JH71.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycolysis; Lyase; Schiff base.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   364  363     Fructose-bisphosphate aldolase B. PRO_0000291611
ACT_SITE   188   188        Proton acceptor (By similarity). 
ACT_SITE   230   230        Schiff-base intermediate with dihydroxyacetone-P (By similarity). 
BINDING   56    56        Substrate (By similarity). 
BINDING   147   147        Substrate (By similarity). 
SITE   364   364  1     Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate (By similarity). 
Sequence information
Length: 364 AA [This is the length of the unprocessed precursor] Molecular weight: 39288 Da [This is the MW of the unprocessed precursor] CRC64: FB2DD9CDDCF4DB9E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTHQFPALST EQKKELATIA ERIVAPGKGI LAADESTGTM AKRFQKINVE NTEENRRSFR 

        70         80         90        100        110        120 
DLLFSVDDSI SESIGGVILF HETLYQKSDK GVLFPKVIKD KGIVVGIKVD KGTAGLAGTD 

       130        140        150        160        170        180 
GETTTQGLDG LSERCAQYKK DGCDFAKWRC VLKISDSCPS ALGIAENANV LARYASICQQ 

       190        200        210        220        230        240 
NGLVPIVEPE ILPDGDHDLK QCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTAGHSC 

       250        260        270        280        290        300 
TKKYTPLEVA MATVTALRRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQL SLHRPWKLSF 

       310        320        330        340        350        360 
SYGRALQASA LSAWKGQAAN KKASQDAFVT RAKINSLASK GEYKPSGQAG QASTQSLFTA 


SYTY
Q8JH71 in FASTA format

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