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UniProtKB/Swiss-Prot entry Q8JH70

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDOC_DANRE
Primary accession number Q8JH70
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 42)
Name and origin of the protein
Protein name Fructose-bisphosphate aldolase C
Synonyms EC 4.1.2.13
Brain-type aldolase
Gene name
Name: aldoc
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/s00239-002-2363-8; PubMed=12486526 [NCBI, ExPASy, EBI, Israel, Japan]
Merritt T.J.S., Quattro J.M.;
"Negative charge correlates with neural expression in vertebrate aldolase isozymes.";
J. Mol. Evol. 55:674-683(2002).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF533647; AAN04478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC053192; AAH53192.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_919365.1; -.
UniGene Dr.19223
3D structure databases
HSSP P00883; 6ALD. [HSSP ENTRY / PDB]
SMR Q8JH70; 3-363.
ModBase Q8JH70.
Organism-specific databases
ZFIN ZDB-GENE-030821-1; aldoc.
Gene expression databases
ArrayExpress Q8JH70; -.
Ontologies
GO
GO:0004332; Molecular function: fructose-bisphosphate aldolase activity (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000741; Aldolase_I.
IPR013785; Aldolase_TIM.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR11627; Aldolase_I; 1.
Pfam PF00274; Glycolytic; 1.
Pfam graphical view of domain structure.
ProDom PD001128; Aldolase_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00158; ALDOLASE_CLASS_I; 1.
Proteomics databases
PRIDE Q8JH70; -.
Genome annotation databases
Ensembl ENSDARG00000019702; Danio rerio. [Contig view]
GeneID 369193; -.
KEGG dre:369193; -.
Phylogenomic databases
HOGENOM Q8JH70; -.
HOVERGEN Q8JH70; -.
Other
ProtoNet Q8JH70.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycolysis; Lyase; Schiff base.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   363  362     Fructose-bisphosphate aldolase C. PRO_0000291612
ACT_SITE   230   230        Schiff-base intermediate with dihydroxyacetone-P (By similarity). 
BINDING   56    56        Substrate (By similarity). 
BINDING   147   147        Substrate (By similarity). 
SITE   363   363  1     Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate (By similarity). 
Sequence information
Length: 363 AA [This is the length of the unprocessed precursor] Molecular weight: 39259 Da [This is the MW of the unprocessed precursor] CRC64: 84D269B36579E6A0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE NTEENRRLYR 

        70         80         90        100        110        120 
QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD RGIVVGIKVD KGVVPLAGTN 

       130        140        150        160        170        180 
GETTTQGLDG LSERCAQYKK DGADFAKWRS VLKISDTTPS ELAIMENANV LARYASICQQ 

       190        200        210        220        230        240 
NGIVPIVEPE ILPDGEHDLK RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC 

       250        260        270        280        290        300 
PTKYSSEEIA MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF 

       310        320        330        340        350        360 
SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG AAGQSLYVAN 


HAY
Q8JH70 in FASTA format

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