[1]	NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. DOI=10.1073/pnas.0504703102; PubMed=16030142 [NCBI, ExPASy, EBI, Israel, Japan] Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K., Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S., Makino H., Kanwar Y.S.; "Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity."; Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Heart; Chen S., Guo J.H., Yu L.; Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Skin; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Expressed in visceral adipose tissues.
SIMILARITY: Belongs to the serpin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY326420; AAP88384.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY177692; AAO18649.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC040857; AAH40857.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_776249.1; -.

UniGene

Hs.99476

3D structure databases

HSSP

P01009; 1QMB. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

ModBase

Q8IW75.

Protein family/group databases

MEROPS

I04.965; -.

Organism-specific databases

GeneCards

GC14M094023; -.

H-InvDB

HIX0026658; -.

HGNC

HGNC:18359; SERPINA12.

PA134863157; -.

Gene expression databases

ArrayExpress

Q8IW75; -.

CleanEx

HS_SERPINA12; -.

GermOnline

ENSG00000165953; Homo sapiens.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004867;	Molecular function: serine-type endopeptidase inhibitor activity (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000215; Protease_inhib_I4_serpin.
Graphical view of domain structure.

PANTHER

PTHR11461; Prot_inh_serpin; 1.

Pfam

PF00079; Serpin; 1.
Pfam graphical view of domain structure.

SMART

SM00093; SERPIN; 1.
SMART graphical view of domain structure.

PROSITE

PS00284; SERPIN; FALSE_NEG.

Proteomics databases

PRIDE

Q8IW75; -.

Genome annotation databases

Ensembl

ENSG00000165953; Homo sapiens. [Contig view]

GeneID

145264; -.

KEGG

hsa:145264; -.

Phylogenomic databases

HOGENOM

Q8IW75; -.

HOVERGEN

Q8IW75; -.

Other

85065; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycoprotein; Polymorphism; Protease inhibitor; Secreted; Serine protease inhibitor; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`By similarity.`
`CHAIN`	`21 414`	`394`	`Serpin A12.`	`PRO_0000041976`
`CARBOHYD`	`221 221`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`233 233`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`267 267`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`142 142`	`1`	`Q -> K (in dbSNP:rs17090972 [NCBI]).`	`VAR_051943`
`VARIANT`	`394 394`	`1`	`I -> V (in dbSNP:rs34519784 [NCBI]).`	`VAR_051944`

Sequence information

Length: 414 AA [This is the length of the unprocessed precursor]

Molecular weight: 47175 Da [This is the MW of the unprocessed precursor]

CRC64: 5C70F1AB5935661C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL 

        70         80         90        100        110        120 
KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII 

       130        140        150        160        170        180 
HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF 

       190        200        210        220        230        240 
ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM 

       250        260        270        280        290        300 
MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS 

       310        320        330        340        350        360 
RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM 

       370        380        390        400        410 
DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK

Q8IW75 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools