[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
PubMed=8302573 [NCBI, ExPASy, EBI, Israel, Japan]
Franke T.F.,
Tartof K.D.,
Tsichlis P.N.;
"The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterisation of the Drosophila melanogaster c-akt homolog Dakt1.";
Oncogene 9:141-148(1994).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE INITIATION (ISOFORMS A AND C), ENZYME ACTIVITY, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
DOI=10.1074/jbc.270.8.4066; PubMed=7876156 [NCBI, ExPASy, EBI, Israel, Japan]
Andjelkovic M.,
Jones P.F.,
Grossniklaus U.,
Cron P.,
Schier A.F.,
Dick M.,
Bilbe G.,
Hemmings B.A.;
"Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase.";
J. Biol. Chem. 270:4066-4075(1995).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D.,
Celniker S.E.,
Holt R.A.,
Evans C.A.,
Gocayne J.D.,
Amanatides P.G.,
Scherer S.E.,
Li P.W.,
Hoskins R.A.,
Galle R.F.,
George R.A.,
Lewis S.E.,
Richards S.,
Ashburner M.,
Henderson S.N.,
Sutton G.G.,
Wortman J.R.,
Yandell M.D.,
Zhang Q., ![]()
Chen L.X.,
Brandon R.C.,
Rogers Y.-H.C.,
Blazej R.G.,
Champe M.,
Pfeiffer B.D.,
Wan K.H.,
Doyle C.,
Baxter E.G.,
Helt G.,
Nelson C.R.,
Miklos G.L.G.,
Abril J.F.,
Agbayani A.,
An H.-J.,
Andrews-Pfannkoch C.,
Baldwin D.,
Ballew R.M.,
Basu A.,
Baxendale J.,
Bayraktaroglu L.,
Beasley E.M.,
Beeson K.Y.,
Benos P.V.,
Berman B.P.,
Bhandari D.,
Bolshakov S.,
Borkova D.,
Botchan M.R.,
Bouck J.,
Brokstein P.,
Brottier P.,
Burtis K.C.,
Busam D.A.,
Butler H.,
Cadieu E.,
Center A.,
Chandra I.,
Cherry J.M.,
Cawley S.,
Dahlke C.,
Davenport L.B.,
Davies P.,
de Pablos B.,
Delcher A.,
Deng Z.,
Mays A.D.,
Dew I.,
Dietz S.M.,
Dodson K.,
Doup L.E.,
Downes M.,
Dugan-Rocha S.,
Dunkov B.C.,
Dunn P.,
Durbin K.J.,
Evangelista C.C.,
Ferraz C.,
Ferriera S.,
Fleischmann W.,
Fosler C.,
Gabrielian A.E.,
Garg N.S.,
Gelbart W.M.,
Glasser K.,
Glodek A.,
Gong F.,
Gorrell J.H.,
Gu Z.,
Guan P.,
Harris M.,
Harris N.L.,
Harvey D.A.,
Heiman T.J.,
Hernandez J.R.,
Houck J.,
Hostin D.,
Houston K.A.,
Howland T.J.,
Wei M.-H.,
Ibegwam C.,
Jalali M.,
Kalush F.,
Karpen G.H.,
Ke Z.,
Kennison J.A.,
Ketchum K.A.,
Kimmel B.E.,
Kodira C.D.,
Kraft C.L.,
Kravitz S.,
Kulp D.,
Lai Z.,
Lasko P.,
Lei Y.,
Levitsky A.A.,
Li J.H.,
Li Z.,
Liang Y.,
Lin X.,
Liu X.,
Mattei B.,
McIntosh T.C.,
McLeod M.P.,
McPherson D.,
Merkulov G.,
Milshina N.V.,
Mobarry C.,
Morris J.,
Moshrefi A.,
Mount S.M.,
Moy M.,
Murphy B.,
Murphy L.,
Muzny D.M.,
Nelson D.L.,
Nelson D.R.,
Nelson K.A.,
Nixon K.,
Nusskern D.R.,
Pacleb J.M.,
Palazzolo M.,
Pittman G.S.,
Pan S.,
Pollard J.,
Puri V.,
Reese M.G.,
Reinert K.,
Remington K.,
Saunders R.D.C.,
Scheeler F.,
Shen H.,
Shue B.C.,
Siden-Kiamos I.,
Simpson M.,
Skupski M.P.,
Smith T.J.,
Spier E.,
Spradling A.C.,
Stapleton M.,
Strong R.,
Sun E.,
Svirskas R.,
Tector C.,
Turner R.,
Venter E.,
Wang A.H.,
Wang X.,
Wang Z.-Y.,
Wassarman D.A.,
Weinstock G.M.,
Weissenbach J.,
Williams S.M.,
Woodage T.,
Worley K.C.,
Wu D.,
Yang S.,
Yao Q.A.,
Ye J.,
Yeh R.-F.,
Zaveri J.S.,
Zhan M.,
Zhang G.,
Zhao Q.,
Zheng L.,
Zheng X.H.,
Zhong F.N.,
Zhong W.,
Zhou X.,
Zhu S.C.,
Zhu X.,
Smith H.O.,
Gibbs R.A.,
Myers E.W.,
Rubin G.M.,
Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
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[4]
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GENOME REANNOTATION, AND ALTERNATIVE INITIATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S.,
Crosby M.A.,
Mungall C.J.,
Matthews B.B.,
Campbell K.S.,
Hradecky P.,
Huang Y.,
Kaminker J.S.,
Millburn G.H.,
Prochnik S.E.,
Smith C.D.,
Tupy J.L.,
Whitfield E.J.,
Bayraktaroglu L.,
Berman B.P.,
Bettencourt B.R.,
Celniker S.E.,
de Grey A.D.N.J.,
Drysdale R.A., ![]()
Harris N.L.,
Richter J.,
Russo S.,
Schroeder A.J.,
Shu S.Q.,
Stapleton M.,
Yamada C.,
Ashburner M.,
Gelbart W.M.,
Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M.,
Carlson J.W.,
Brokstein P.,
Yu C.,
Champe M.,
George R.A.,
Guarin H.,
Kronmiller B.,
Pacleb J.M.,
Park S.,
Wan K.H.,
Rubin G.M.,
Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
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[6]
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FUNCTION, AND MUTAGENESIS OF PHE-408.
DOI=10.1016/S0960-9822(98)70231-3; PubMed=9601646 [NCBI, ExPASy, EBI, Israel, Japan]
Staveley B.E.,
Ruel L.,
Jin J.,
Stambolic V.,
Mastronardi F.G.,
Heitzler P.,
Woodgett J.R.,
Manoukian A.S.;
"Genetic analysis of protein kinase B (AKT) in Drosophila.";
Curr. Biol. 8:599-602(1998).
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[7]
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FUNCTION, AND MUTAGENESIS OF LYS-295.
DOI=10.1038/70293; PubMed=10587646 [NCBI, ExPASy, EBI, Israel, Japan]
Verdu J.,
Buratovich M.A.,
Wilder E.L.,
Birnbaum M.J.;
"Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.";
Nat. Cell Biol. 1:500-506(1999).
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[8]
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FUNCTION, AND PHOSPHORYLATION AT SER-586.
DOI=10.1038/sj.onc.1203739; PubMed=10962553 [NCBI, ExPASy, EBI, Israel, Japan]
Scanga S.E.,
Ruel L.,
Binari R.C.,
Snow B.,
Stambolic V.,
Bouchard D.,
Peters M.,
Calvieri B.,
Mak T.W.,
Woodgett J.R.,
Manoukian A.S.;
"The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila.";
Oncogene 19:3971-3977(2000).
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[9]
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FUNCTION.
DOI=10.1016/S1534-5807(01)00090-9; PubMed=11740943 [NCBI, ExPASy, EBI, Israel, Japan]
Jin J.,
Anthopoulos N.,
Wetsch B.,
Binari R.C.,
Isaac D.D.,
Andrew D.J.,
Woodgett J.R.,
Manoukian A.S.;
"Regulation of Drosophila tracheal system development by protein kinase B.";
Dev. Cell 1:817-827(2001).
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[10]
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PHOSPHORYLATION.
DOI=10.1073/pnas.101596998; PubMed=11344272 [NCBI, ExPASy, EBI, Israel, Japan]
Cho K.S.,
Lee J.H.,
Kim S.,
Kim D.,
Koh H.,
Lee J.,
Kim C.,
Kim J.,
Chung J.;
"Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.";
Proc. Natl. Acad. Sci. U.S.A. 98:6144-6149(2001).
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[11]
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FUNCTION.
DOI=10.1073/pnas.011318098; PubMed=11752451 [NCBI, ExPASy, EBI, Israel, Japan]
Rintelen F.,
Stocker H.,
Thomas G.,
Hafen E.;
"PDK1 regulates growth through Akt and S6K in Drosophila.";
Proc. Natl. Acad. Sci. U.S.A. 98:15020-15025(2001).
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[12]
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FUNCTION.
DOI=10.1038/ncb840; PubMed=12172554 [NCBI, ExPASy, EBI, Israel, Japan]
Potter C.J.,
Pedraza L.G.,
Xu T.;
"Akt regulates growth by directly phosphorylating Tsc2.";
Nat. Cell Biol. 4:658-665(2002).
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[13]
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FUNCTION, AND MUTAGENESIS OF GLY-180 AND PHE-408.
DOI=10.1126/science.1068094; PubMed=11872800 [NCBI, ExPASy, EBI, Israel, Japan]
Stocker H.,
Andjelkovic M.,
Oldham S.,
Laffargue M.,
Wymann M.P.,
Hemmings B.A.,
Hafen E.;
"Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.";
Science 295:2088-2091(2002).
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[14]
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FUNCTION.
DOI=10.1096/fj.03-0040fje; PubMed=14525946 [NCBI, ExPASy, EBI, Israel, Japan]
Lavenburg K.R.,
Ivey J.,
Hsu T.,
Muise-Helmericks R.C.;
"Coordinated functions of Akt/PKB and ETS1 in tubule formation.";
FASEB J. 17:2278-2280(2003).
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[15]
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FUNCTION.
DOI=10.1101/gad.1098703; PubMed=12893776 [NCBI, ExPASy, EBI, Israel, Japan]
Puig O.,
Marr M.T.,
Ruhf M.L.,
Tjian R.;
"Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.";
Genes Dev. 17:2006-2020(2003).
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[16]
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FUNCTION.
DOI=10.1101/gad.1240504; PubMed=15466161 [NCBI, ExPASy, EBI, Israel, Japan]
Dong J.,
Pan D.;
"Tsc2 is not a critical target of Akt during normal Drosophila development.";
Genes Dev. 18:2479-2484(2004).
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[17]
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FUNCTION, AND DEVELOPMENTAL STAGE.
DOI=10.1002/dvdy.20333; PubMed=15712201 [NCBI, ExPASy, EBI, Israel, Japan]
Cavaliere V.,
Donati A.,
Hsouna A.,
Hsu T.,
Gargiulo G.;
"dAkt kinase controls follicle cell size during Drosophila oogenesis.";
Dev. Dyn. 232:845-854(2005).
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[18]
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DEPHOSPHORYLATION AT SER-586.
DOI=10.1016/j.molcel.2005.03.008; PubMed=15808505 [NCBI, ExPASy, EBI, Israel, Japan]
Gao T.,
Furnari F.,
Newton A.C.;
"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.";
Mol. Cell 18:13-24(2005).
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[19]
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PHOSPHORYLATION AT SER-586.
DOI=10.1126/science.1106148; PubMed=15718470 [NCBI, ExPASy, EBI, Israel, Japan]
Sarbassov D.D.,
Guertin D.A.,
Ali S.M.,
Sabatini D.M.;
"Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.";
Science 307:1098-1101(2005).
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[20]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND MASS SPECTROMETRY.
TISSUE=Embryo;
DOI=10.1021/pr700696a; PubMed=18327897 [NCBI, ExPASy, EBI, Israel, Japan]
Zhai B.,
Villen J.,
Beausoleil S.A.,
Mintseris J.,
Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
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