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UniProtKB/Swiss-Prot entry Q8HYE4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL1A1_MACFA
Primary accession number Q8HYE4
Secondary accession numbers None
Integrated into Swiss-Prot on February 16, 2004
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 38)
Name and origin of the protein
Protein name Retinal dehydrogenase 1
Synonyms RALDH 1
RalDH1
EC 1.2.1.36
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
ALHDII
ALDH-E1
Gene name
Name: ALDH1A1
From
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney proximal tubule;
DOI=10.1194/jlr.M200359-JLR200; PubMed=12576512 [NCBI, ExPASy, EBI, Israel, Japan]
Brodeur H., Gagnon I., Mader S., Bhat P.V.;
"Cloning of monkey RALDH1 and characterization of retinoid metabolism in monkey kidney proximal tubule cells.";
J. Lipid Res. 44:303-313(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF542418; AAN85861.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase Q8HYE4.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0001758; Molecular function: retinal dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
Phylogenomic databases
HOVERGEN Q8HYE4; -.
Other
ProtoNet Q8HYE4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   501  500     Retinal dehydrogenase 1. PRO_0000056416
NP_BIND   246   251  6     NAD (By similarity). 
ACT_SITE   269   269        Proton acceptor (By similarity). 
ACT_SITE   303   303        Nucleophile (By similarity). 
SITE   170   170  1     Transition state stabilizer (By similarity). 
MOD_RES   2     2        N-acetylserine (By similarity). 
Sequence information
Length: 501 AA [This is the length of the unprocessed precursor] Molecular weight: 54736 Da [This is the MW of the unprocessed precursor] CRC64: E3864A9190BBD6B2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSSGTSDLP VLPTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKADV 

        70         80         90        100        110        120 
DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL 

       130        140        150        160        170        180 
NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI 

       190        200        210        220        230        240 
GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID 

       250        260        270        280        290        300 
KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG 

       310        320        330        340        350        360 
QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGA TQGPQIDKEQ YDKILDLIES 

       370        380        390        400        410        420 
GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR 

       430        440        450        460        470        480 
ANNTFYGLSA GVFTNDIDKA VTISSALQAG TVWVNCYGVV TAQCPFGGFK MSGNGRELGE 

       490        500 
YGFHEYTEVK TVTVKISQKN S
Q8HYE4 in FASTA format

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