ID   TGAS_STRCJ              Reviewed;         416 AA.
AC   Q8GR90;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   04-NOV-2008, entry version 28.
DE   RecName: Full=Protein-glutamine gamma-glutamyltransferase;
DE            EC=2.3.2.13;
DE   AltName: Full=Transglutaminase;
DE            Short=TGase;
DE   Flags: Precursor;
OS   Streptomyces cinnamoneus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=53446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11874 / DSM 40005 / IFO 12852 / JCM 4633 / NCIMB 8851;
RA   Yokoyama K.;
RT   "Streptoverticillium cinnamoneum IFO12852 TGase gene.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the cross-linking of proteins and the
CC       conjugation of polyamines to proteins (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)-
CC       alkylglutamine + NH(3).
CC   -!- PTM: Predicted to be exported by the Tat system. The position of
CC       the signal peptide cleavage has not been experimentally proven.
CC   -!- SIMILARITY: Belongs to the bacterial TGase family.
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DR   EMBL; AB085698; BAC24766.1; -; Genomic_DNA.
DR   HSSP; P81453; 1IU4.
DR   SMR; Q8GR90; 87-416.
DR   GO; GO:0008415; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase...; IEA:EC.
DR   InterPro; IPR006311; Tat.
DR   InterPro; IPR015107; Transglut_prok.
DR   Pfam; PF09017; Transglut_prok; 1.
DR   PIRSF; PIRSF037210; Transglut_prok; 1.
DR   TIGRFAMs; TIGR01409; TAT_signal_seq; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Signal; Transferase; Zymogen.
FT   SIGNAL        1     29       Tat-type signal (Potential).
FT   PROPEP       30     85       By similarity.
FT                                /FTId=PRO_0000033658.
FT   CHAIN        86    416       Protein-glutamine gamma-
FT                                glutamyltransferase (By similarity).
FT                                /FTId=PRO_0000033659.
FT   ACT_SITE    149    149       By similarity.
FT   ACT_SITE    340    340       By similarity.
FT   ACT_SITE    359    359       By similarity.
SQ   SEQUENCE   416 AA;  46394 MW;  677DA9778829839D CRC64;
     MHKRRRLLAF ATVGAVICTA GFTPSVSQAA SSGDGEEKGS YAETHGLTAD DVESINALNE
     RALTLGQPGK PPKELPPSAS APSRAPSDDR ETPPAEPLDR MPEAYRAYGG RATTVVNNYI
     RKWQQVYSHR DGKKQQMTEE QREKLSYGCV GVTWVNSGPY PTNRLAFASF DENKYKNDLK
     NTSPRPDETR AEFEGRIAKG SFDEGKGFKR ARDVASVMNK ALENAHDEGT YINNLKTELT
     NNNDALLRED SRSNFYSALR NTPSFKERDG GNYDPSKMKA VIYSKHFWSG QDQRGSSDKR
     KYGDPEAFRP DQGTGLVDMS KDRSIPRSPA KPGEGWVNFD YGWFGAQTEA DADKTTWTHG
     DHYHAPNSDL GPMHVHESKF RKWSAGYADF DRGAYVITFI PKSWNTAPAK VEQGWP
//