[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 11874 / DSM 40005 / IFO 12852 / JCM 4633 / NCIMB 8851; Yokoyama K.; "Streptoverticillium cinnamoneum IFO12852 TGase gene."; Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins (By similarity).
CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N⁵-alkylglutamine + NH₃.
PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
SIMILARITY: Belongs to the bacterial TGase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB085698; BAC24766.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P81453; 1IU4. [HSSP ENTRY / PDB]

SMR

Q8GR90; 87-416.

ModBase

Q8GR90.

Ontologies

GO:0008415;	Molecular function: acyltransferase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0003810;	Molecular function: protein-glutamine gamma-glutamyltransferase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006311; Tat.
IPR015107; Transglut_prok.
Graphical view of domain structure.

Pfam

PF09017; Transglut_prok; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF037210; Transglut_prok; 1.

TIGRFAMs

TIGR01409; TAT_signal_seq; 1.

PROSITE

PS51318; TAT; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q8GR90.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acyltransferase; Signal; Transferase; Zymogen.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 29`	`29`	`Tat-type signal (Potential).`
`PROPEP`	`30 85`	`56`	`By similarity.`	`PRO_0000033658`
`CHAIN`	`86 416`	`331`	`Protein-glutamine gamma-glutamyltransferase (By similarity).`	`PRO_0000033659`
`ACT_SITE`	`149 149`		`By similarity.`
`ACT_SITE`	`340 340`		`By similarity.`
`ACT_SITE`	`359 359`		`By similarity.`

Sequence information

Length: 416 AA [This is the length of the unprocessed precursor]

Molecular weight: 46394 Da [This is the MW of the unprocessed precursor]

CRC64: 677DA9778829839D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHKRRRLLAF ATVGAVICTA GFTPSVSQAA SSGDGEEKGS YAETHGLTAD DVESINALNE 

        70         80         90        100        110        120 
RALTLGQPGK PPKELPPSAS APSRAPSDDR ETPPAEPLDR MPEAYRAYGG RATTVVNNYI 

       130        140        150        160        170        180 
RKWQQVYSHR DGKKQQMTEE QREKLSYGCV GVTWVNSGPY PTNRLAFASF DENKYKNDLK 

       190        200        210        220        230        240 
NTSPRPDETR AEFEGRIAKG SFDEGKGFKR ARDVASVMNK ALENAHDEGT YINNLKTELT 

       250        260        270        280        290        300 
NNNDALLRED SRSNFYSALR NTPSFKERDG GNYDPSKMKA VIYSKHFWSG QDQRGSSDKR 

       310        320        330        340        350        360 
KYGDPEAFRP DQGTGLVDMS KDRSIPRSPA KPGEGWVNFD YGWFGAQTEA DADKTTWTHG 

       370        380        390        400        410 
DHYHAPNSDL GPMHVHESKF RKWSAGYADF DRGAYVITFI PKSWNTAPAK VEQGWP

Q8GR90 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools