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UniProtKB/Swiss-Prot entry Q8G7C4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDL_BIFLO
Primary accession number Q8G7C4
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 42)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase
Synonyms EC 6.3.2.4
D-alanylalanine synthetase
D-Ala-D-Ala ligase
Gene name
Name: ddl
Synonyms: ddlA
OrderedLocusNames: BL0345
From
Bifidobacterium longum [TaxID: 216816] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCC 2705;
DOI=10.1073/pnas.212527599; PubMed=12381787 [NCBI, ExPASy, EBI, Israel, Japan]
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract.";
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014295; AAN24184.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_695548.1; -.
3D structure databases
HSSP P25051; 1E4E. [HSSP ENTRY / PDB]
ModBase Q8G7C4.
Enzyme and pathway databases
BioCyc BLON206672:BL0345-MON; -.
Ontologies
GO
GO:0005618; Cellular component: cell wall (inferred from electronic annotation from InterPro).
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 1023250; -.
GenomeReviews AE014295_GR; BL0345.
KEGG blo:BL0345; -.
NMPDR fig|206672.1.peg.317; -.
Phylogenomic databases
HOGENOM Q8G7C4; -.
Genome annotation databases
CMR Q8G7C4; BL0345.
Other
ProtoNet Q8G7C4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   428  428     D-alanine--D-alanine ligase. PRO_0000177787
DOMAIN   205   424  220     ATP-grasp. 
NP_BIND   237   299  63     ATP (By similarity). 
METAL   378   378        Magnesium or manganese 1 (By similarity). 
METAL   391   391        Magnesium or manganese 1 (By similarity). 
METAL   391   391        Magnesium or manganese 2 (By similarity). 
METAL   393   393        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46045 Da [This is the MW of the unprocessed precursor] CRC64: D501772E024C8F46 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRLLCAAFRA RFGPVGGAKH RLENGCSFNK RMVMAKKRVV VLYGGRADEH SISCISTAGV 

        70         80         90        100        110        120 
LGAMDTERFE PIPVGITKDG KWIINGEDPR GWNLDGGELP TVKITPESRP VMLDPSRGQD 

       130        140        150        160        170        180 
GFFIGEPSHI NSADSGFGTS FVSMSDPEMH HVLTSLGHVD AVLPVLHGPY GEDGTVQGLL 

       190        200        210        220        230        240 
EMMGVPYVGC GVFASAACMD KHYTKVVLDA AGIPTAPGVT VDARNFTAAD VLAEIEDAGL 

       250        260        270        280        290        300 
TYPLFVKPSR AGSSFGVTKV EKADDRETQQ DRLAAAIATA GEHDWKVLVE QGIDGREIEC 

       310        320        330        340        350        360 
AVLCPKAGDE PEASWPGEIV LDHQNDDQFY DFDSKYMDAS ASHVEVPANL PVSVLEDVRD 

       370        380        390        400        410        420 
VARRAFKAVD GAGLSRVDTF VTPDGTVMVN EINTMPGFTP ISMYPKAWDA TGVSYTELIT 


RLIEGVLR
Q8G7C4 in FASTA format

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