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UniProtKB/Swiss-Prot entry Q8G044

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDLA_BRUSU
Primary accession number Q8G044
Secondary accession numbers None
Integrated into Swiss-Prot on October 31, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase A
Synonyms EC 6.3.2.4
D-alanylalanine synthetase A
D-Ala-D-Ala ligase A
Gene name
Name: ddlA
OrderedLocusNames: BR1271
From
Brucella suis [TaxID: 29461] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1330 / Biovar 1;
DOI=10.1073/pnas.192319099; PubMed=12271122 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.";
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014291; AAN30189.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_698274.1; -.
3D structure databases
HSSP P07862; 1IOW. [HSSP ENTRY / PDB]
ModBase Q8G044.
Enzyme and pathway databases
BioCyc BSUI204722:BR_1271-MON; -.
Ontologies
GO
GO:0005618; Cellular component: cell wall (inferred from electronic annotation from InterPro).
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 1166950; -.
GenomeReviews AE014291_GR; BR1271.
KEGG bms:BR1271; -.
NMPDR fig|204722.1.peg.1231; -.
TIGR BR1271; -.
Phylogenomic databases
HOGENOM Q8G044; -.
Other
ProtoNet Q8G044.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   353  353     D-alanine--D-alanine ligase A. PRO_0000177796
DOMAIN   141   346  206     ATP-grasp. 
NP_BIND   169   224  56     ATP (By similarity). 
METAL   300   300        Magnesium or manganese 1 (By similarity). 
METAL   313   313        Magnesium or manganese 1 (By similarity). 
METAL   313   313        Magnesium or manganese 2 (By similarity). 
METAL   315   315        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 37560 Da [This is the MW of the unprocessed precursor] CRC64: 655D7EED0CE1366E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASGKMRIVV LFGGRSAEHD VSVLSATNVM NALDPAKYEA VPVFVTRAGQ WLLSRFVNGA 

        70         80         90        100        110        120 
LEKPSSGAEL CLVPGGCGRA IVVPDAGAPY EADKIDIIFP VLHGLHGEDG AVQGLAQVAR 

       130        140        150        160        170        180 
VPLAGCGIPG SANALDKDIA KRLVNEAGLS TAKSVTITRE EVPAFSALEQ ALGLPIFIKP 

       190        200        210        220        230        240 
ARQGSSVGVH KVVTEADYQA AMSDGFTYDD KLLAEEFIQA REVECGVLED EGGALFVSRA 

       250        260        270        280        290        300 
GEIVPAESHC FYSYDAKYID ADGTEIKVPA ELPEQVENEI RAIATRAFRV LGCDSMARVD 

       310        320        330        340        350 
FFVTADRRIV LNEINTIPGF TDMSMYSKVM AVSGVSYPEI INRLVAHGLA RGS
Q8G044 in FASTA format

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