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UniProtKB/Swiss-Prot entry Q8F6S7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ODO1_LEPIN
Primary accession number Q8F6S7
Secondary accession numbers None
Integrated into Swiss-Prot on January 24, 2006
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 35)
Name and origin of the protein
Protein name 2-oxoglutarate dehydrogenase E1 component
Synonyms EC 1.2.4.2
Alpha-ketoglutarate dehydrogenase
Gene name
Name: sucA
Synonyms: odhA
OrderedLocusNames: LA_1224
From
Leptospira interrogans [TaxID: 173] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
DOI=10.1038/nature01597; PubMed=12712204 [NCBI, ExPASy, EBI, Israel, Japan]
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.";
Nature 422:888-893(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010300; AAN48423.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_711405.1; -.
3D structure databases
ModBase Q8F6S7.
Enzyme and pathway databases
BioCyc LINT189518:LA1224-MON; -.
Ontologies
GO
GO:0004591; Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from electronic annotation from HAMAP).
GO:0030976; Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01169; -; 1.
PBIL [Tree]
InterPro IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.
PANTHER PTHR23152; 2oxoglutarate_DH_E1; 1.
Pfam PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000157; Oxoglu_dh_E1; 1.
TIGRFAMs TIGR00239; 2oxo_dh_E1; 1.
Genome annotation databases
GeneID 1150567; -.
GenomeReviews AE010300_GR; LA_1224.
KEGG lil:LA1224; -.
Phylogenomic databases
HOGENOM Q8F6S7; -.
Genome annotation databases
CMR Q8F6S7; LA_1224.
Other
ProtoNet Q8F6S7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   920  920     2-oxoglutarate dehydrogenase E1 component. PRO_0000162174
Sequence information
Length: 920 AA [This is the length of the unprocessed precursor] Molecular weight: 103922 Da [This is the MW of the unprocessed precursor] CRC64: 8A4513F3F1B3DD0A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIEKLMALY GENGALLEEL YNQYKLNPET LDKEWKSFFQ EVDTNGLANG SGYTNGNGKS 

        70         80         90        100        110        120 
AVATSFTDAQ AASIREMGII NLLNAYRRQG HLAAKLDPLG IQKPNRTFID SKLHNISPAD 

       130        140        150        160        170        180 
IDTVVDSETL GRVKLAEIVD LYEKVYCNTI GAEHFYLVND EEREWLQKKM ESPEFLAPLP 

       190        200        210        220        230        240 
RGIKLRLFEK LFQADYFETF LAKKYVGKKR FSLEGGESFI PLLDTIVEEA GYHQMDGLVI 

       250        260        270        280        290        300 
GMAHRGRLNV LVNIIEKPAS LIFAEFEEKT DKDNLSYADV KYHLGYSNSR MTTSGKEVKL 

       310        320        330        340        350        360 
SLAFNPSHLE CVDPVVTGSV RARQTLIGDK DRSKYMPILI HGDAAFAGQG VVAETLNLMN 

       370        380        390        400        410        420 
LEGYTTGGTF HIVVNNQIGF TTLPDESRST LYATDLAKGF QIPIIHVNGD DPEAVYRVVK 

       430        440        450        460        470        480 
LGMEYRQKFK KDFIIDLVCY RRLGHNETDE PAFTQPKMYA IIKNHPPTVK LYEKRLVEEG 

       490        500        510        520        530        540 
DIPQEDIDFI KNGSMHGLED SFQRAKEQDV KIRVDTMQGV WSKFSKDSLD SEPATKLLAE 

       550        560        570        580        590        600 
QMHGIVQALT SVPQGFTPNS KLVKLLQSRK EMAEGKIPVD WGFAEALSFG SILESGFRIR 

       610        620        630        640        650        660 
LSGQDSQRGT FSHRHAVLVD TNTNEKYIPL NHISSKQAKA EIINSSLSEF SVLGFEYGYS 

       670        680        690        700        710        720 
LSDPNALVMW EAQFGDFANS AQVIFDQFIS SSEVKWQRLS GLIMLLPHGY EGQGPEHSSA 

       730        740        750        760        770        780 
RLERFLQLCA LDNMQVCNLT TAAQYFHLLR RQMLRNYRKP LVIVTPKSLL RFPASLSPVE 

       790        800        810        820        830        840 
DILQGAFREI LIDDSGSKPD KIEKVVFSAG KVYYDLMKYK DENKIKNVAL VRVEQIYPFP 

       850        860        870        880        890        900 
AKEIQSSLKT FKNAKQFVWC QEEPKNQGAW FFVRERIEEL LPGNARLVYA GRHESPSPAA 

       910        920 
GHMKLHLQEQ DQLVLDAFQA
Q8F6S7 in FASTA format

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