NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DSM 14371 / JCM 11309 / KCTC 3954 / HTE831;
DOI=10.1093/nar/gkf526; PubMed=12235376 [NCBI, ExPASy, EBI, Israel, Japan]
Takami H., Takaki Y., Uchiyama I.;
"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments.";
Nucleic Acids Res. 30:3927-3935(2002).

Comments

FUNCTION: Reduction of activated sulfate into sulfite.
CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000028; BAC13608.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_692573.1; -.

3D structure databases

ModBase

Q8EQP2.

Enzyme and pathway databases

BioCyc

OIHE221109:OB1652-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004604;	Molecular function: phosphoadenylyl-sulfate reductase (thioredoxin) activity (inferred from electronic annotation from HAMAP).
GO:0016740;	Molecular function: transferase activity (inferred from electronic annotation from InterPro).
GO:0019344;	Biological process: cysteine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019379;	Biological process: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00063; -; 1.
PBIL [Tree]

InterPro

IPR011798; APS_reductase.
IPR004511; CysH.
IPR002500; PAPS_reduct.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.

Pfam

PF01507; PAPS_reduct; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02055; APS_reductase; 1.
TIGR00434; cysH; 1.

Genome annotation databases

1018148; -.

BA000028_GR; OB1652.

oih:OB1652; -.

fig|221109.1.peg.1655; -.

Phylogenomic databases

HOGENOM

Q8EQP2; -.

Genome annotation databases

CMR

Q8EQP2; OB1652.

Other

ProtoNet

Q8EQP2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 240`	`240`		`Phosphoadenosine phosphosulfate reductase.`	`PRO_1000008931`

Sequence information

Length: 240 AA [This is the length of the unprocessed precursor]

Molecular weight: 27407 Da [This is the MW of the unprocessed precursor]

CRC64: 083D781AA9190CD9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGGYSVTYSN FVKDPYKDWF PDDETNGASK ILQWAYEVYG TDIVYACSFG AEGMVLIDLI 

        70         80         90        100        110        120 
SKTQKNADIV FLDTDLHFQE TYDLIEDIKV KYPTLNIHIK KPDLTLEEQA AEHGSALWKR 

       130        140        150        160        170        180 
QPDQCCYIRK IKPLEDALSG APAWISGLRR EQSVSRSKTD FINKDERFKS IKVCPLIHWT 

       190        200        210        220        230        240 
WDDVWEYIKD NNLPYNELHD NGYPSIGCIP CTSQVSDSSD SRAGRWAGTQ KTECGLHTSD

Q8EQP2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools