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UniProtKB/Swiss-Prot entry Q8E0N5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHD_STRA5
Primary accession number Q8E0N5
Secondary accession numbers None
Integrated into Swiss-Prot on November 28, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 40)
Name and origin of the protein
Protein name D-lactate dehydrogenase
Synonyms D-LDH
EC 1.1.1.28
D-specific D-2-hydroxyacid dehydrogenase
Gene name
Name: ldhD
Synonyms: ldhA
OrderedLocusNames: SAG0695
From
Streptococcus agalactiae serotype V [TaxID: 216466] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-611 / 2603 V/R / Serotype V;
DOI=10.1073/pnas.182380799; PubMed=12200547 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D., Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A., Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.";
Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014223; AAM99582.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_687710.1; -.
3D structure databases
HSSP P17584; 1DXY. [HSSP ENTRY / PDB]
ModBase Q8E0N5.
Ontologies
GO
GO:0008720; Molecular function: D-lactate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; 1.
Genome annotation databases
GeneID 1013499; -.
GenomeReviews AE009948_GR; SAG0695.
KEGG sag:SAG0695; -.
TIGR SAG0695; -.
Phylogenomic databases
HOGENOM Q8E0N5; -.
Other
ProtoNet Q8E0N5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     D-lactate dehydrogenase. PRO_0000075969
ACT_SITE   235   235        By similarity. 
ACT_SITE   264   264        By similarity. 
ACT_SITE   296   296        Proton donor (By similarity). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 36560 Da [This is the MW of the unprocessed precursor] CRC64: 1F1589D42E3C9BF5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKLKVFNVRE EEATLAQDWA NRNHVELSMS EGPLTLETVN EVEGFDGIAN AQIEPLDDAI 

        70         80         90        100        110        120 
YPLLKEMGIK QIAQRSAGVD MYNLELAKQH GIIISNVPSY SPESIAEFTV TIALNLIRKV 

       130        140        150        160        170        180 
ELIRANVREQ NFSWTLPIRG RVLGNMTVAI IGTGRIGLAT AKIFKGFGCR VIGYDIYHNP 

       190        200        210        220        230        240 
MADGILEYVN SVEEAVEEAD LVSLHMPPTA ENTHLFNLDM FKQFKKGAIL MNMARGALVE 

       250        260        270        280        290        300 
TKDLLEALDQ GLLEGAGIDT YEFEGPYIPK NCQGQDISDK DFLRLINHPK VIYTPHAAYY 

       310        320        330 
TDEAVKNLVE GALNACVEVI ETGTTTTKVN
Q8E0N5 in FASTA format

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