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UniProtKB/Swiss-Prot entry Q8CWQ5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MURE_STRR6
Primary accession number Q8CWQ5
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2004
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Synonyms EC 6.3.2.7
UDP-MurNAc-L-Ala-D-Glu:L-Lys ligase
L-lysine-adding enzyme
UDP-N-acetylmuramyl-tripeptide synthetase
UDP-MurNAc-tripeptide synthetase
Gene name
Name: murE
OrderedLocusNames: spr1384
From
Streptococcus pneumoniae (strain ATCC BAA-255 / R6) [TaxID: 171101] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.183.19.5709-5717.2001; PubMed=11544234 [NCBI, ExPASy, EBI, Israel, Japan]
Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
"Genome of the bacterium Streptococcus pneumoniae strain R6.";
J. Bacteriol. 183:5709-5717(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE008508; AAL00188.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G98044; G98044.
RefSeq NP_358977.1; -.
3D structure databases
ModBase Q8CWQ5.
Enzyme and pathway databases
BioCyc SPNE171101:SPR1384-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0047482; Molecular function: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity (inferred from electronic annotation from EC).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from InterPro).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00208; -; 1.
PBIL [Tree]
InterPro IPR004101; Mur_ligase_C.
IPR013221; Mur_ligase_cen.
IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase.
Graphical view of domain structure.
Gene3D G3DSA:3.90.190.20; Mur_ligase_C; 1.
G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
Pfam PF02875; Mur_ligase_C; 1.
PF08245; Mur_ligase_M; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01085; murE; 1.
Genome annotation databases
GeneID 934603; -.
GenomeReviews AE007317_GR; spr1384.
KEGG spr:spr1384; -.
Phylogenomic databases
HOGENOM Q8CWQ5; -.
Genome annotation databases
CMR Q8CWQ5; spr1384.
Other
ProtoNet Q8CWQ5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   481  481     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. PRO_0000101954
NP_BIND   118   124  7     ATP (Potential). 
REGION   160   161  2     UDP-MurNAc-L-Ala-D-Glu binding (By similarity). 
MOTIF   404   407  4     L-lysine recognition motif. 
BINDING   42    42        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
BINDING   187   187        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
BINDING   195   195        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
MOD_RES   229   229        N6-carboxylysine (By similarity). 
Sequence information
Length: 481 AA [This is the length of the unprocessed precursor] Molecular weight: 53828 Da [This is the MW of the unprocessed precursor] CRC64: 9A668127E05341E5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIKIETVLDI LKKDGLFREI IDQGHYHYNY SKVIFDSISY DSRKVTEDTL FFAKGAAFKK 

        70         80         90        100        110        120 
EYLLSAITQG LAWYVAEKDY EVDIPVIIVN DIKKAMSLIA MEFYGNPQEK LKLLAFTGTK 

       130        140        150        160        170        180 
GKTTATYFAY NILSQGHRPA MLSTMNTTLD GETFFKSALT TPESIDLFDM MNQAVQNDRT 

       190        200        210        220        230        240 
HLIMEVSSQA YLVHRVYGLT FDVGVFLNIT PDHIGPIEHP SFEDYFYHKR LLMENSRAVI 

       250        260        270        280        290        300 
INSDMDHFSV LKEQVEDQDH DFYGSQFDNQ IENSKAFSFS ATGKLAGDYD IQLIGNFNQE 

       310        320        330        340        350        360 
NAVAAGLACL RLGASLEDIK KGIAATRVPG RMEVLTQKNG AKVFIDYAHN GDSLKKLINV 

       370        380        390        400        410        420 
VETHQTGKIA LVLGSTGNKG ESRRKDFGLL LNQHPEIQVF LTADDPNYED PMAIADEISS 

       430        440        450        460        470        480 
YINHPVEKIA DRQEAIKAAM AITNHELDAV IIAGKGADCY QIIQGKKESY PGDTAVAENY 


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Q8CWQ5 in FASTA format

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