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UniProtKB/Swiss-Prot entry Q8CIN7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IMPA2_RAT
Primary accession number Q8CIN7
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2005
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 39)
Name and origin of the protein
Protein name Inositol monophosphatase 2
Synonyms EC 3.1.3.25
Inositol-1(or 4)-monophosphatase 2
IMPase 2
IMP 2
Myo-inositol monophosphatase A2
Gene name
Name: Impa2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
Parthasarathy L., Seelan R., Parthasarathy R.;
"Molecular cloning and sequencing of rat Impa2.";
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY160191; AAN47010.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC083544; AAH83544.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_757378.1; -.
UniGene Rn.856
3D structure databases
HSSP P29218; 1IMF. [HSSP ENTRY / PDB]
SMR Q8CIN7; 17-283.
ModBase Q8CIN7.
Organism-specific databases
RGD 628692; Impa2.
Gene expression databases
ArrayExpress Q8CIN7; -.
GermOnline ENSRNOG00000018516; Rattus norvegicus.
Ontologies
GO
GO:0008934; Molecular function: inositol-1(or 4)-monophosphatase activity (inferred from electronic annotation from EC).
GO:0031403; Molecular function: lithium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000760; Inositol_P.
Graphical view of domain structure.
PANTHER PTHR20854; Inositol_P; 1.
Pfam PF00459; Inositol_P; 1.
Pfam graphical view of domain structure.
PRINTS PR00378; INOSPHPHTASE.
ProDom PD023420; Inositol_P; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00629; IMP_1; 1.
PS00630; IMP_2; 1.
Genome annotation databases
Ensembl ENSRNOG00000018516; Rattus norvegicus. [Contig view]
GeneID 282636; -.
KEGG rno:282636; -.
Phylogenomic databases
HOVERGEN Q8CIN7; -.
Other
NextBio 624837; -.
ProtoNet Q8CIN7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Lithium; Magnesium; Metal-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   290  290     Inositol monophosphatase 2. PRO_0000142522
METAL   83    83        Magnesium 1 (By similarity). 
METAL   103   103        Magnesium 1 (By similarity). 
METAL   103   103        Magnesium 2 (By similarity). 
METAL   105   105        Magnesium 1; via carbonyl oxygen (By similarity). 
METAL   106   106        Magnesium 2 (By similarity). 
METAL   233   233        Magnesium 2 (By similarity). 
Sequence information
Length: 290 AA [This is the length of the unprocessed precursor] Molecular weight: 31796 Da [This is the MW of the unprocessed precursor] CRC64: 6DF985B2BD99F266 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPNSEEEEE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKHVSTKT SAADLVTETD 

        70         80         90        100        110        120 
HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV 

       130        140        150        160        170        180 
SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR 

       190        200        210        220        230        240 
DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI 

       250        260        270        280        290 
IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
Q8CIN7 in FASTA format

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