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UniProtKB/Swiss-Prot entry Q8CHR6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPYD_MOUSE
Primary accession number Q8CHR6
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 45)
Name and origin of the protein
Protein name Dihydropyrimidine dehydrogenase [NADP+]
Synonyms DHPDHase
DPD
EC 1.3.1.2
Dihydrouracil dehydrogenase
Dihydrothymine dehydrogenase
Gene name
Name: Dpyd
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC039699; AAH39699.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_740748.1; -.
UniGene Mm.27907
3D structure databases
HSSP Q28943; 1GTE. [HSSP ENTRY / PDB]
SMR Q8CHR6; 2-1017.
ModBase Q8CHR6.
PTM databases
PhosphoSite Q8CHR6; -.
Organism-specific databases
MGI MGI:2139667; Dpyd.
Gene expression databases
ArrayExpress Q8CHR6; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from MGI).
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from InterPro).
GO:0017113; Molecular function: dihydropyrimidine dehydrogenase (NADP+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006207; Biological process: 'de novo' pyrimidine base biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006214; Biological process: thymidine catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006212; Biological process: uracil catabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000759; Adrndx_reductase.
IPR013785; Aldolase_TIM.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR012285; Fum_reductase_C.
IPR016040; NAD(P)-bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01180; DHO_dh; 1.
PF00037; Fer4; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 3.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8CHR6; -.
Genome annotation databases
Ensembl ENSMUSG00000033308; Mus musculus. [Contig view]
GeneID 99586; -.
KEGG mmu:99586; -.
Phylogenomic databases
HOGENOM Q8CHR6; -.
HOVERGEN Q8CHR6; -.
Other
NextBio 354029; -.
SOURCE Dpyd; Mus musculus.
ProtoNet Q8CHR6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Cytoplasm; FAD; Flavoprotein; FMN; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1025  1025     Dihydropyrimidine dehydrogenase [NADP+]. PRO_0000327501
DOMAIN   69    100  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   944    976  33     4Fe-4S ferredoxin-type 2. 
DOMAIN   978   1007  30     4Fe-4S ferredoxin-type 3. 
METAL   953    953        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   956    956        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   959    959        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   963    963        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   986    986        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   989    989        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   992    992        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   996    996        Iron-sulfur 2 (4Fe-4S) (Potential). 
MOD_RES   577    577        Phosphoserine (By similarity). 
Sequence information
Length: 1025 AA [This is the length of the unprocessed precursor] Molecular weight: 111253 Da [This is the MW of the unprocessed precursor] CRC64: AA1D1B3E3B72C504 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGVLSRDAP DIESILALNP RVQAHATLRS TAAKKLDKKH WKRNTDKNCF TCEKLESNFD 

        70         80         90        100        110        120 
DIKHTTLGER GALREAVRCL KCADAPCQKS CPTSLDIKSF ITSIANKNYY GAAKLIFSDN 

       130        140        150        160        170        180 
PLGLTCGMVC PTSDLCVGGC NLHAAEEGPI NIGGLQQFAT EVFKAMNIPQ IRNPSLPPPE 

       190        200        210        220        230        240 
HMPEAYSAKI ALFGAGPASI SCASFLARLG YSNITIFEKQ EYVGGLSTSE IPQFRLPYDV 

       250        260        270        280        290        300 
VNFEIELMKD LGVKIICGKS LSTDEMTLSS LKENGYRAAF IGIGLPEPKK DHIFQGLTQV 

       310        320        330        340        350        360 
QGFYTSKDFL PLVAKSSKTG MCACHSPLPS IRGAVIVLGA GDTAFDCATS ALRCGALRVF 

       370        380        390        400        410        420 
IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKD GKIVAMQFVR TEQDETGNWV 

       430        440        450        460        470        480 
EDEEQTVRLK ADVVISAFGS VLEDPKVKEA LSPIKFNRWG LPEVNPETMQ TSEPWVFAGG 

       490        500        510        520        530        540 
DVVGMANTTV ESVNDGKQAS WYIHKHIQAQ YGTSVPSQPT MPLFYTPVDL VDISVEMAGL 

       550        560        570        580        590        600 
RFPNPFGLAS ATPATSTPMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPLY 

       610        620        630        640        650        660 
GPGQSSFLNI ELISEKTAAY WCHSVTELKA DFPDNILIAS IMCSYNKSDW MELSKMAEAS 

       670        680        690        700        710        720 
GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ AVRVPFFAKL TPNVTDIVSI 

       730        740        750        760        770        780 
ARAAKEGGAD GVTATNTVSG LMGLKADGTP WPAVGIGRRT TYGGVSGTAI RPIALRAVTA 

       790        800        810        820        830        840 
IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL 

       850        860        870        880        890        900 
KSIEELADWD GQSPPIISHQ KGKPVPRVAE LMGQKLPSFG PYLEQRKKII AASKIRQKDQ 

       910        920        930        940        950        960 
NTACSPLQRK HFNSQKPIPA IKDVIGKSLQ YLGTFGEMSI MEQVVALIDE EMCINCGKCY 

       970        980        990       1000       1010       1020 
MTCNDSGYQA IQFDPETHLP TVSDTCTGCT LCLSVCPIMD CIRMVSRATP YQPKRGLPLA 


VKPVC
Q8CHR6 in FASTA format

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