[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Hartley; Itoh K., Takahashi Y., Kitagawa M., Kamataki T.; "Inhibition of the transcription of the guinea pig NAD(P)H: quinone oxidoreductase1 (NQO1) gene by specificity protein 1 (Sp1)."; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis (By similarity).
CATALYTIC ACTIVITY: NAD(P)H + a quinone = NAD(P)⁺ + a hydroquinone.
COFACTOR: FAD (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the NAD(P)H dehydrogenase (quinone) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB055403; BAC53985.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P15559; 1H69. [HSSP ENTRY / PDB]

SMR

Q8CHK7; 5-275.

ModBase

Q8CHK7.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0050662;	Molecular function: coenzyme binding (inferred from electronic annotation from InterPro).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0003955;	Molecular function: NAD(P)H dehydrogenase (quinone) activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003680; Flavodoxin_fold.
Graphical view of domain structure.

Pfam

PF02525; Flavodoxin_2; 1.
Pfam graphical view of domain structure.

Genome annotation databases

Ensembl

ENSCPOG00000012430; Cavia porcellus. [Contig view]

Phylogenomic databases

HOVERGEN

Q8CHK7; -.

Other

ProtoNet

Q8CHK7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; FAD; Flavoprotein; NAD; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 275`	`275`		`NAD(P)H dehydrogenase [quinone] 1.`	`PRO_0000071621`

Sequence information

Length: 275 AA [This is the length of the unprocessed precursor]

Molecular weight: 31086 Da [This is the MW of the unprocessed precursor]

CRC64: 15C475E39A7176C0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP IISRKDITGA 

        70         80         90        100        110        120 
LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI FQFPLQWFGV PAILKGWFER 

       130        140        150        160        170        180 
VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT GGSESMYSLK GIHGDMNIIL WPIQSGTLHF 

       190        200        210        220        230        240 
CGFQVLEPQL TYGIGHTPPD VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL 

       250        260        270 
KKEIEDEQKN NKYGLSVGHH LGKPIPTDNQ IKARK

Q8CHK7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools