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UniProtKB/Swiss-Prot entry Q8CFI2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UB2R1_MOUSE
Primary accession number Q8CFI2
Secondary accession number Q505K8
Integrated into Swiss-Prot on April 26, 2004
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 50)
Name and origin of the protein
Protein name Ubiquitin-conjugating enzyme E2 R1
Synonyms EC 6.3.2.19
Ubiquitin-protein ligase R1
Ubiquitin-conjugating enzyme E2-32 kDa complementing
E2-CDC34
Gene name
Name: Cdc34
Synonyms: Ube2r1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129, and C57BL/6J;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC039160; AAH39160.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC094502; AAH94502.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_808281.1; -.
XP_001478177.1; -.
UniGene Mm.21981
3D structure databases
HSSP P34477; 1PZV. [HSSP ENTRY / PDB]
SMR Q8CFI2; 9-181.
ModBase Q8CFI2.
Protein-protein interaction databases
IntAct Q8CFI2; 2.
Organism-specific databases
MGI MGI:102657; Cdc34.
Gene expression databases
ArrayExpress Q8CFI2; -.
CleanEx MM_CDC34; -.
GermOnline ENSMUSG00000020307; Mus musculus.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004842; Molecular function: ubiquitin-protein ligase activity (inferred from electronic annotation from EC).
GO:0043687; Biological process: post-translational protein modification (inferred from electronic annotation from InterPro).
GO:0051246; Biological process: regulation of protein metabolic process (inferred from electronic annotation from InterPro).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8CFI2; -.
Genome annotation databases
Ensembl ENSMUSG00000020307; Mus musculus. [Contig view]
GeneID 100046898; -.
216150; -.
KEGG mmu:100046898; -.
mmu:216150; -.
Phylogenomic databases
HOGENOM Q8CFI2; -.
HOVERGEN Q8CFI2; -.
Other
NextBio 460338; -.
SOURCE Cdc34; Mus musculus.
ProtoNet Q8CFI2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Ligase; Phosphoprotein; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   235  235     Ubiquitin-conjugating enzyme E2 R1. PRO_0000082452
COMPBIAS   200   235  36     Asp/Glu-rich (acidic). 
ACT_SITE   93    93        Glycyl thioester intermediate (By similarity). 
MOD_RES   230   230        Phosphoserine; by CK2 (By similarity). 
Sequence information
Length: 235 AA [This is the length of the unprocessed precursor] Molecular weight: 26622 Da [This is the MW of the unprocessed precursor] CRC64: 3259FA0CD407E1E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA 

        70         80         90        100        110        120 
RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV 

       130        140        150        160        170        180 
RTILLSVISL LNEPNTFSPA NVDASVMYRK WKESKGKDRE YTDIIRKQVL GTKVDAERDG 

       190        200        210        220        230 
VKVPTTLAEY CVKTKAPAPD EGSDLFYDDY YEDGEVEEAD SCFGDEEDDS GTEES
Q8CFI2 in FASTA format

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