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UniProtKB/Swiss-Prot entry Q8BZ25


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ANKK1_MOUSE
Primary accession number Q8BZ25
Secondary accession numbers None
Integrated into Swiss-Prot on January 24, 2006
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 48)
Name and origin of the protein
Protein name Ankyrin repeat and protein kinase domain-containing protein 1
Synonym EC 2.7.11.1
Gene name
Name: Ankk1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Vagina;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK036872; BAC29613.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_766510.1; -.
UniGene Mm.119994
3D structure databases
HSSP Q60778; 1OY3. [HSSP ENTRY / PDB]
ModBase Q8BZ25.
PTM databases
PhosphoSite Q8BZ25; -.
Organism-specific databases
MGI MGI:3045301; Ankk1.
Gene expression databases
ArrayExpress Q8BZ25; -.
CleanEx MM_ANKK1; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from InterPro).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002110; ANK.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.20; ANK; 2.
Pfam PF00023; Ank; 11.
PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
PRINTS PR01415; ANKYRIN.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00248; ANK; 11.
SMART graphical view of domain structure.
PROSITE PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 11.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8BZ25; -.
Genome annotation databases
Ensembl ENSMUSG00000032257; Mus musculus. [Contig view]
GeneID 244859; -.
KEGG mmu:244859; -.
Phylogenomic databases
HOGENOM Q8BZ25; -.
HOVERGEN Q8BZ25; -.
Other
NextBio 386440; -.
SOURCE Ankk1; Mus musculus.
ProtoNet Q8BZ25.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ANK repeat; ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Repeat; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   745  745     Ankyrin repeat and protein kinase domain-containing protein 1. PRO_0000085621
DOMAIN   34   301  268     Protein kinase. 
REPEAT   369   398  30     ANK 1. 
REPEAT   402   431  30     ANK 2. 
REPEAT   435   464  30     ANK 3. 
REPEAT   468   497  30     ANK 4. 
REPEAT   501   530  30     ANK 5. 
REPEAT   534   563  30     ANK 6. 
REPEAT   567   596  30     ANK 7. 
REPEAT   600   629  30     ANK 8. 
REPEAT   633   662  30     ANK 9. 
REPEAT   666   695  30     ANK 10. 
REPEAT   699   728  30     ANK 11. 
NP_BIND   40    48  9     ATP (By similarity). 
ACT_SITE   157   157        Proton acceptor (By similarity). 
BINDING   63    63        ATP (By similarity). 
MOD_RES   702   702        Phosphothreonine (By similarity). 
Sequence information
Length: 745 AA [This is the length of the unprocessed precursor] Molecular weight: 82480 Da [This is the MW of the unprocessed precursor] CRC64: DDD391ECD19EB84D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVPHRARRLL NPMAVGPLAQ QLGSLTVFTR DDFEEEWHLV ASGGFSKVFQ ARHKRWRTQY 

        70         80         90        100        110        120 
AIKCSPCLQK ETTSSEVTCL FEEAVKMEKI KFQHIVSIYG VCKQPLGIVM EFMASGSLEK 

       130        140        150        160        170        180 
TLPTHSLCWP LKLRIIHETS LAMNFLHSIK PPLLHLDLKP GNILLDNNMH VKISDFGLSK 

       190        200        210        220        230        240 
WMEQSTQKQY IERSALRGTL SYIPPEMFLE NNKAPGPEYD VYSFAIVIWE ILTQKKPYAG 

       250        260        270        280        290        300 
LNMMTIIIRV AAGMRPSLQD VSDEWPEEVH QMVNLMKRCW DQDPKKRPCF LNVAVETDML 

       310        320        330        340        350        360 
LSLFQSPMTD PGCEALTQKV SCKPSLSQPH KVSKEVNQEI ADSVSSDSLK WILQLSDSKS 

       370        380        390        400        410        420 
LVASDVYENR VTPLHFLVAG GSLEQVRLLL SHDVDVDCQT ASGYTPLLIA TQDQQPDLCA 

       430        440        450        460        470        480 
LLLAHGADTN LADEDGWAPL HFAAQNGDDH TARLLLDHGA LVNAREHEGW TPLHLAAQNN 

       490        500        510        520        530        540 
FENVARLLVS RQADLSPHEA EGKTPLHVAA YFGHIGLVKL LSGQGAELDA QQRNLRTPLH 

       550        560        570        580        590        600 
LAVERGKVRA IQHLLKCGAL PDALDHSGYS PLHIAAARGK DLIFKMLLRY GASLELRTQQ 

       610        620        630        640        650        660 
GWTPLHLATY KGHLEIIHQL AKSHVDLDAL GSMQWTPLHL AAFQGEEGVM LALLQCGANP 

       670        680        690        700        710        720 
NAAEQSGWTP LHLAVHKGTF LGITHLLEYG ADIHACNKVG WTPAHLAALK GNTAILKVLV 

       730        740 
KAAAQVDVKG GVSCTPLQLA IHSPK 

Q8BZ25 in FASTA format

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