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UniProtKB/Swiss-Prot entry Q8BGW1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FTO_MOUSE
Primary accession number Q8BGW1
Secondary accession numbers Q3TTZ5 Q6ZPI7 Q8BR68 Q8CB66 Q8R250 Q9QZ13
Integrated into Swiss-Prot on May 1, 2007
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 42)
Name and origin of the protein
Protein name Protein fto
Synonyms Fat mass and obesity-associated protein
Protein fatso
Gene name
Name: Fto
Synonyms: Kiaa1752
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1007/s003359901144; PubMed=10501967 [NCBI, ExPASy, EBI, Israel, Japan]
Peters T., Ausmeier K., Ruether U.;
"Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation.";
Mamm. Genome 10:983-986(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1093/dnares/10.4.167; PubMed=14621295 [NCBI, ExPASy, EBI, Israel, Japan]
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
STRAIN=C57BL/6J, and NOD;
TISSUE=Aorta, Bone, Corpora quadrigemina, Skin, Thymus, and Vein;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6, and FVB/N;
TISSUE=Brain, and Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ237917; CAB59324.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK129437; BAC98247.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK036677; BAC29533.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK040866; BAC30724.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK045465; BAC32382.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK049502; BAC33780.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK088881; BAC40629.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK161060; BAE36177.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022222; AAH22222.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057008; AAH57008.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_036066.2; -.
UniGene Mm.4375
3D structure databases
ModBase Q8BGW1.
PTM databases
PhosphoSite Q8BGW1; -.
Organism-specific databases
MGI MGI:1347093; Fto.
Gene expression databases
ArrayExpress Q8BGW1; -.
CleanEx MM_FTO; -.
Ontologies
GO
GO:0007368; Biological process: determination of left/right symmetry (inferred from expression pattern from HGNC).
GO:0030326; Biological process: embryonic limb morphogenesis (inferred from expression pattern from HGNC).
QuickGo view.
Genome annotation databases
Ensembl ENSMUSG00000055932; Mus musculus. [Contig view]
GeneID 26383; -.
KEGG mmu:26383; -.
Phylogenomic databases
HOVERGEN Q8BGW1; -.
Other
NextBio 304305; -.
SOURCE Fto; Mus musculus.
ROUGE KIAA1752.
ProtoNet Q8BGW1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Obesity.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   502  502     Protein fto. PRO_0000286164
VAR_SEQ   296   316        DDLNATHQHCVLAGSQPRFSS -> GNVGSLRVGHLWGFEIHFWIL (in isoform 4). VSP_025007
VAR_SEQ   317   502        Missing (in isoform 4). VSP_025008
VAR_SEQ   411   413        TNA -> VSA (in isoform 3). VSP_025009
VAR_SEQ   414   502        Missing (in isoform 3). VSP_025010
VAR_SEQ   453   502        CQSRVVRTLPVQQKPDCRPYWEKDDPSMPLPFDLTDVVSE LRGQLLEARS -> FVLLRGGVWCPCPSSARPAQRTKVEDILS (in isoform 2). VSP_025011
CONFLICT   181   181        G -> R (in Ref. 3; BAC32382). 
CONFLICT   384   384        N -> S (in Ref. 1; CAB59324, 2; BAC98247, 3; BAC40629 and 4; AAH22222). 
CONFLICT   410   410        M -> V (in Ref. 2; BAC98247, 3; BAC40629 and 4; AAH22222). 
CONFLICT   463   463        V -> A (in Ref. 3; BAC40629 and 4; AAH22222). 
Sequence information
Length: 502 AA [This is the length of the unprocessed precursor] Molecular weight: 58007 Da [This is the MW of the unprocessed precursor] CRC64: 69223B824028D872 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 

        70         80         90        100        110        120 
LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 

       130        140        150        160        170        180 
KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 

       190        200        210        220        230        240 
GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 

       250        260        270        280        290        300 
VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 

       310        320        330        340        350        360 
THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 

       370        380        390        400        410        420 
LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 

       430        440        450        460        470        480 
EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM 

       490        500 
PLPFDLTDVV SELRGQLLEA RS 

Q8BGW1 in FASTA format

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