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UniProtKB/Swiss-Prot entry Q8ABA9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BACTN
Primary accession number Q8ABA9
Secondary accession numbers None
Integrated into Swiss-Prot on June 6, 2003
Sequence was last modified on June 6, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 49)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BT_0201
From
Bacteroides thetaiotaomicron [TaxID: 818] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015928; AAO75308.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_809114.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q8ABA9.
Enzyme and pathway databases
BioCyc BTHE226186:BT_0201-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
Genome annotation databases
GeneID 1074912; -.
GenomeReviews AE015928_GR; BT_0201.
KEGG bth:BT_0201; -.
NMPDR fig|226186.1.peg.201; -.
Phylogenomic databases
HOGENOM Q8ABA9; -.
Genome annotation databases
CMR Q8ABA9; BT_0201.
Other
ProtoNet Q8ABA9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Histidinol dehydrogenase. PRO_0000135732
ACT_SITE   323   323        Proton acceptor (By similarity). 
ACT_SITE   324   324        Proton acceptor (By similarity). 
METAL   256   256        Zinc (By similarity). 
METAL   259   259        Zinc (By similarity). 
METAL   357   357        Zinc (By similarity). 
METAL   416   416        Zinc (By similarity). 
BINDING   125   125        NAD (By similarity). 
BINDING   187   187        NAD (By similarity). 
BINDING   210   210        NAD (By similarity). 
BINDING   234   234        Substrate (By similarity). 
BINDING   256   256        Substrate (By similarity). 
BINDING   259   259        Substrate (By similarity). 
BINDING   324   324        Substrate (By similarity). 
BINDING   357   357        Substrate (By similarity). 
BINDING   411   411        Substrate (By similarity). 
BINDING   416   416        Substrate (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46246 Da [This is the MW of the unprocessed precursor] CRC64: 3C7BEEFF3BA154D1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MMKLIKYPSK EQWAELLKRP ALNTESLFDT VRTIINKVRA EGDKAVLEYE AAFDKVTLSA 

        70         80         90        100        110        120 
LTVTSEEIQK AEGLISDELK SAITLAKRNI ETFHSSQRFV GKKVETMEGV TCWQKAVGIE 

       130        140        150        160        170        180 
KVGLYIPGGT APLFSTVLML AVPAKIAGCR EIVLCTPPDK NGNIHPAILF AAQLAGVSKI 

       190        200        210        220        230        240 
FKAGGVQAIA AMAYGTESVP KVYKIFGPGN QYVTAAKQLV SLRDVAIDMP AGPSEVEVLA 

       250        260        270        280        290        300 
DASANPVFVA ADLLSQAEHG VDSQAMLITT SEKLQAEVME EVNRQLAKLP RREIAAKSLE 

       310        320        330        340        350        360 
NSKLILVKDM DEALELTNAY APEHLIVETE NYLEVAERVI NAGSVFLGSL TPESAGDYAS 

       370        380        390        400        410        420 
GTNHTLPTNG YAKAYSGVSL DSFIRKITFQ EILPQGMKVI GPAIEEMAAN ELLDAHKNAV 


TVRLNTLK
Q8ABA9 in FASTA format

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