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UniProtKB/Swiss-Prot entry Q8A6M0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BACTN
Primary accession number Q8A6M0
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 46)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BT_1857
From
Bacteroides thetaiotaomicron [TaxID: 818] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015928; AAO76964.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_810770.1; -.
3D structure databases
HSSP P12010; 2AYQ. [HSSP ENTRY / PDB]
ModBase Q8A6M0.
Enzyme and pathway databases
BioCyc BTHE226186:BT_1857-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
Genome annotation databases
GeneID 1075934; -.
GenomeReviews AE015928_GR; BT_1857.
KEGG bth:BT_1857; -.
NMPDR fig|226186.1.peg.1857; -.
Phylogenomic databases
HOGENOM Q8A6M0; -.
Genome annotation databases
CMR Q8A6M0; BT_1857.
Other
ProtoNet Q8A6M0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   353  353     3-isopropylmalate dehydrogenase. PRO_0000083646
METAL   219   219        Magnesium or manganese (By similarity). 
METAL   243   243        Magnesium or manganese (By similarity). 
METAL   247   247        Magnesium or manganese (By similarity). 
BINDING   97    97        Substrate (By similarity). 
BINDING   107   107        Substrate (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   219   219        Substrate (By similarity). 
SITE   142   142  1     Important for catalysis (By similarity). 
SITE   187   187  1     Important for catalysis (By similarity). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 39179 Da [This is the MW of the unprocessed precursor] CRC64: 9D6A32F7EBB2B077 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDFKIAVLAG DGIGPEISVQ GVDVMSAVCE KFGHKVSYEY AICGADAIDK VGDPFPEETY 

        70         80         90        100        110        120 
EVCKNADAVL FSAVGDPKFD NDPTAKVRPE QGLLAMRKKL GLFANIRPVQ TFKCLIHKSP 

       130        140        150        160        170        180 
LRAELVENAD FICIRELTGG MYFGEKYQDN DKAYDTNYYT RPEIERILKV AFEYAMKRRK 

       190        200        210        220        230        240 
HLTVVDKANV LASSRLWRQI AQEMAPNYPE VTTDYMFVDN AAMKMIQEPA FFDVMVTENT 

       250        260        270        280        290        300 
FGDILTDEGS VISGSMGLLP SASTGESTPV FEPIHGSWPQ AKGLNIANPL AQILSVAMLF 

       310        320        330        340        350 
EYFDCKEEGA LIRKAVDASL DENVRTPEIQ VADGAKYGTK EVGQWIVDYI KKA
Q8A6M0 in FASTA format

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