ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8A256

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name MURD_BACTN
Primary accession number Q8A256
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on April 26, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms EC 6.3.2.9
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
D-glutamic acid-adding enzyme
Gene name
Name: murD
OrderedLocusNames: BT_3450
From
Bacteroides thetaiotaomicron [TaxID: 818] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015928; AAO78556.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_812362.1; -.
3D structure databases
HSSP P14900; 1EEH. [HSSP ENTRY / PDB]
ModBase Q8A256.
Enzyme and pathway databases
BioCyc BTHE226186:BT_3450-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0008764; Molecular function: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity (inferred from electronic annotation from HAMAP).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from InterPro).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00639; -; 1.
PBIL [Tree]
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR004101; Mur_ligase_C.
IPR013221; Mur_ligase_cen.
IPR016040; NAD(P)-bd.
IPR005762; UDP-N-AcMur-Glu_ligase.
Graphical view of domain structure.
Gene3D G3DSA:3.90.190.20; Mur_ligase_C; 1.
G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02875; Mur_ligase_C; 1.
PF08245; Mur_ligase_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
TIGRFAMs TIGR01087; murD; 1.
Genome annotation databases
GeneID 1074391; -.
GenomeReviews AE015928_GR; BT_3450.
KEGG bth:BT_3450; -.
NMPDR fig|226186.1.peg.3449; -.
Phylogenomic databases
HOGENOM Q8A256; -.
Genome annotation databases
CMR Q8A256; BT_3450.
Other
ProtoNet Q8A256.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   444  444     UDP-N-acetylmuramoylalanine--D-glutamate ligase. PRO_0000108970
NP_BIND   109   115  7     ATP (Potential). 
Sequence information
Length: 444 AA [This is the length of the unprocessed precursor] Molecular weight: 49492 Da [This is the MW of the unprocessed precursor] CRC64: 541FED7F141F0770 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKRIVILGAG ESGAGAAVLA KVKGFETFVS DMSAIKDKYK DLLDSHHIAW EEGHHTEELI 

        70         80         90        100        110        120 
LNADEVIKSP GIPNDAPLIL KLKAQGTPVI SEIEFAGRYT DAKMICITGS NGKTTTTSLI 

       130        140        150        160        170        180 
YHIFKSADLN VGLAGNIGKS LALQVAEEHH DYYIIELSSF QLDNMYNFRA NIAVLMNITP 

       190        200        210        220        230        240 
DHLDRYDHCM QNYIDAKFRI TQNQTTDDAF IFWNDDPIIK QELAKHGLKA HLYPFAAVKE 

       250        260        270        280        290        300 
DGAIAYVEDH EVKITEPIAF NMEQEELALT GQHNLYNSLA AGISANLAGI TKENIRKALS 

       310        320        330        340        350        360 
DFKGVEHRLE KVARVRGIDF INDSKATNVN SCWYALQSMT TKTVLILGGK DKGNDYTEIE 

       370        380        390        400        410        420 
DLVREKCSAL VYLGLHNEKL HAFFDRFGLP VADVQTGMKD AVEAAYKLAK KGETVLLSPC 

       430        440 
CASFDLFKSY EDRGDQFKKY VREL
Q8A256 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!