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UniProtKB/Swiss-Prot entry Q60759

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCDH_MOUSE
Primary accession number Q60759
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Glutaryl-CoA dehydrogenase, mitochondrial [Precursor]
Synonyms GCD
EC 1.3.99.7
Gene name
Name: Gcdh
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129/Sv;
TISSUE=Liver;
DOI=10.1006/geno.1995.1182; PubMed=7490088 [NCBI, ExPASy, EBI, Israel, Japan]
Koeller D.M., Digiulio K.A., Angeloni S.V., Dowler L.L., Frerman F.E., White R.A., Goodman S.I.;
"Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene.";
Genomics 28:508-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U18992; AAB04679.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.2475
3D structure databases
HSSP Q06319; 1BUC. [HSSP ENTRY / PDB]
SMR Q60759; 48-435.
ModBase Q60759.
PTM databases
PhosphoSite Q60759; -.
Organism-specific databases
MGI MGI:104541; Gcdh.
Gene expression databases
ArrayExpress Q60759; -.
CleanEx MM_GCDH; -.
GermOnline ENSMUSG00000003809; Mus musculus.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from direct assay from MGI).
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004361; Molecular function: glutaryl-CoA dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006089; Acyl-CoA_DHase_CS.
IPR006092; Acyl-CoA_DHase_N.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
Pfam PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
PF02771; Acyl-CoA_dh_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00072; ACYL_COA_DH_1; FALSE_NEG.
PS00073; ACYL_COA_DH_2; 1.
ProtoNet Q60759.
Genome annotation databases
Ensembl ENSMUSG00000003809; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q60759; -.
HOVERGEN Q60759; -.
Other
SOURCE Gcdh; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    44  44     Mitochondrion (Potential). 
CHAIN   45   438  394     Glutaryl-CoA dehydrogenase, mitochondrial. PRO_0000000528
ACT_SITE   414   414        Proton acceptor (Potential). 
Sequence information
Length: 438 AA [This is the length of the unprocessed precursor] Molecular weight: 48647 Da [This is the MW of the unprocessed precursor] CRC64: B91D78319067753E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLRGVSAQL LSRRSGLRFP RFPRTWSSAA AHTEKTQIRP AKSSRPVFDW KDPLILEEQL 

        70         80         90        100        110        120 
TADEKLIRDT FRNYWQERLM SQILLANRNE VFHRDIVYEM GELGVLGPTI KGYGCAGVSS 

       130        140        150        160        170        180 
VAYGLLTREL ERVDSGYRSM MSVQSSLVMH PIYTYGSEEQ RQKYLPRLAK GELLGCFGLT 

       190        200        210        220        230        240 
EPNHGSDPGG METRARHNPS NQSYTLSGTK TWITNSPVAD LFIVWARCED NCIPGFILEK 

       250        260        270        280        290        300 
GMRGSSAPRI EGKFSLRASA TGMIIMDSVE VPEENVLPNV SSLAGPFGCL NTARYGITWG 

       310        320        330        340        350        360 
VLGAAEFCLH TARQYALDRI QFGVPLARNQ LVQKKLADML TEITLGLHAC LQLGRLKDQD 

       370        380        390        400        410        420 
KATPEMVSML KRNNCGKALD IARQARDILG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH 

       430 
ALILGRAITG IQAFTVGK
Q60759 in FASTA format

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