NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1007/s00203-004-0742-9; PubMed=15551059 [NCBI, ExPASy, EBI, Israel, Japan]
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.;
"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1.";
Arch. Microbiol. 183:27-36(2005).

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR555306; CAI07062.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_157963.1; -.

3D structure databases

ModBase

Q5P6J9.

Enzyme and pathway databases

BioCyc

ASP76114:EBA1735-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050661;	Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

Genome annotation databases

GeneID

3181023; -.

GenomeReviews

CR555306_GR; AZOSEA09370.

KEGG

eba:ebA1735; -.

NMPDR

fig|76114.4.peg.378; -.

Phylogenomic databases

HOGENOM

Q5P6J9; -.

Genome annotation databases

CMR

Q5P6J9; AZOSEA09370.

Other

ProtoNet

Q5P6J9.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 279`	`279`	`Shikimate dehydrogenase.`	`PRO_1000021257`
`NP_BIND`	`128 132`	`5`	`NADP (By similarity).`
`ACT_SITE`	`67 67`		`Proton acceptor (Potential).`

Sequence information

Length: 279 AA [This is the length of the unprocessed precursor]

Molecular weight: 29287 Da [This is the MW of the unprocessed precursor]

CRC64: B5F011E2F3666C14 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTIDRYAVIG NPISHSRSPA IHAEFARQTG QQLSYEALLA PLDGFRDAVE RFRRAGGRGM 

        70         80         90        100        110        120 
NVTVPFKLEA FALTDRCAPR ASAAGAVNTL AFGPDGIFGD NTDGAGLIRD IVHNLDRPLE 

       130        140        150        160        170        180 
RQRVLLLGAG GAARGVLLPL LAARPASLTL ANRSVDKAHA LAAAFRSHAP DVALDACSFV 

       190        200        210        220        230        240 
DLAGRVFDVV INATAASLAN EAPQLPPGLY AANALAYDMM YGCGDTPFLA AARSDGATQR 

       250        260        270 
ADGLGMLVEQ AAESFLLWRG VRPDTAAVLA ALRRQLDGG

Q5P6J9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools