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UniProtKB/Swiss-Prot entry Q5HLA0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHD_STAEQ
Primary accession number Q5HLA0
Secondary accession numbers None
Integrated into Swiss-Prot on December 20, 2005
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 31)
Name and origin of the protein
Protein name D-lactate dehydrogenase
Synonyms D-LDH
EC 1.1.1.28
D-specific D-2-hydroxyacid dehydrogenase
Gene name
Name: ldhD
Synonyms: ddh
OrderedLocusNames: SERP2087
From
Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [TaxID: 176279] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.187.7.2426-2438.2005; PubMed=15774886 [NCBI, ExPASy, EBI, Israel, Japan]
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.;
"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.";
J. Bacteriol. 187:2426-2438(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000029; AAW52941.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_189643.1; -.
3D structure databases
ModBase Q5HLA0.
Enzyme and pathway databases
BioCyc SEPI176279:SERP2087-MON; -.
Ontologies
GO
GO:0008720; Molecular function: D-lactate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; 1.
PS00671; D_2_HYDROXYACID_DH_3; 1.
Genome annotation databases
GeneID 3241781; -.
GenomeReviews CP000029_GR; SERP2087.
KEGG ser:SERP2087; -.
TIGR SERP2087; -.
Phylogenomic databases
HOGENOM Q5HLA0; -.
Other
ProtoNet Q5HLA0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     D-lactate dehydrogenase. PRO_0000075967
ACT_SITE   235   235        By similarity. 
ACT_SITE   264   264        By similarity. 
ACT_SITE   296   296        Proton donor (By similarity). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 36526 Da [This is the MW of the unprocessed precursor] CRC64: E49590DB57226722 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKIMFFGTR AYEKDMALRW GKKNNIDVTT STELLSVDTV DQLKDYDGVT TMQFGKLEPE 

        70         80         90        100        110        120 
VYPKLESYGI KQIAQRTAGF DMYDLELAKK HEIIISNIPS YSPETIAEYS VSIALQLVRK 

       130        140        150        160        170        180 
FPTIEKRVQA HNFTWASPIM SRPVKNMTVA IIGTGRIGAA TGKIYAGFGA RVVGYDAYPN 

       190        200        210        220        230        240 
HSLSFLEYKE TVEDAIKDAD IISLHVPANK DSFHLFDNNM FKNVKKGAVL VNAARGAVIN 

       250        260        270        280        290        300 
TPDLIEAVNN GTLSGAAIDT YENEANYFTF DCSNQTIDDP ILLDLIRNEN ILVTPHIAFF 

       310        320        330 
SDEAVQNLVE GGLNAALSVI NTGTCDTRLN
Q5HLA0 in FASTA format

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