[1]	NUCLEOTIDE SEQUENCE [MRNA]. Ethier J.-F., Lussier J.G., Daneau I., Silversides D.W.; "Bovine activin receptor type I can be expressed as a kinase-domain truncated receptor."; Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May also bind activin.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 GS domain.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U58095; AAB02696.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Bt.16020

3D structure databases

HSSP

P36897; 1IAS. [HSSP ENTRY / PDB]

ModBase

Q28041.

Ontologies

GO:0048179;	Cellular component: activin receptor complex (inferred from sequence or structural similarity from AgBase).
GO:0016361;	Molecular function: activin receptor activity, type I (inferred from sequence or structural similarity from AgBase).
GO:0050431;	Molecular function: transforming growth factor beta binding (inferred from sequence or structural similarity from AgBase).
GO:0007368;	Biological process: determination of left/right symmetry (inferred from sequence or structural similarity from AgBase).
GO:0007281;	Biological process: germ cell development (inferred from sequence or structural similarity from AgBase).
GO:0007507;	Biological process: heart development (inferred from sequence or structural similarity from AgBase).
GO:0001701;	Biological process: in utero embryonic development (inferred from sequence or structural similarity from AgBase).
GO:0001755;	Biological process: neural crest cell migration (inferred from sequence or structural similarity from AgBase).
GO:0007179;	Biological process: transforming growth factor beta receptor signaling pathway (inferred from sequence or structural similarity from AgBase).
GO:0001655;	Biological process: urogenital system development (inferred from sequence or structural similarity from AgBase).
QuickGo view.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.

Pfam

PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00467; GS; 1.
SMART graphical view of domain structure.

PROSITE

PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q28041.

Genome annotation databases

Ensembl

ENSBTAG00000011909; Bos taurus. [Contig view]

Phylogenomic databases

HOVERGEN

Q28041; -.

Other

ProtoNet

Q28041.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`By similarity.`
`CHAIN`	`21 509`	`489`	`Activin receptor type-1.`	`PRO_0000024393`
`TOPO_DOM`	`21 123`	`103`	`Extracellular (Potential).`
`TRANSMEM`	`124 146`	`23`	`Potential.`
`TOPO_DOM`	`147 509`	`363`	`Cytoplasmic (Potential).`
`DOMAIN`	`178 207`	`30`	`GS.`
`DOMAIN`	`208 502`	`295`	`Protein kinase.`
`NP_BIND`	`214 222`	`9`	`ATP (By similarity).`
`ACT_SITE`	`336 336`		`Proton acceptor (By similarity).`
`BINDING`	`235 235`		`ATP (By similarity).`
`MOD_RES`	`501 501`		`Phosphoserine (By similarity).`
`CARBOHYD`	`102 102`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 509 AA [This is the length of the unprocessed precursor]

Molecular weight: 57190 Da [This is the MW of the unprocessed precursor]

CRC64: 365B9D4A518773FB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVDGVMILPV LVMIAFPFPS MEDEKPKVNP KLYMCVCEGL SCGDEAHCEG QQCFSSLSIN 

        70         80         90        100        110        120 
DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 

       130        140        150        160        170        180 
HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 

       190        200        210        220        230        240 
ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 

       250        260        270        280        290        300 
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 

       310        320        330        340        350        360 
DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 

       370        380        390        400        410        420 
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 

       430        440        450        460        470        480 
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 

       490        500 
NPSARLTALR IKKTLTKIDN SLDKLKTDC

Q28041 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools