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UniProtKB/Swiss-Prot entry Q00961

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NMDE3_RAT
Primary accession number Q00961
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 73)
Name and origin of the protein
Protein name Glutamate [NMDA] receptor subunit epsilon-3 [Precursor]
Synonyms N-methyl D-aspartate receptor subtype 2C
NMDAR2C
NR2C
Gene name
Name: Grin2c
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=1350383 [NCBI, ExPASy, EBI, Israel, Japan]
Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., Seeburg P.H.;
"Heteromeric NMDA receptors: molecular and functional distinction of subtypes.";
Science 256:1217-1221(1992).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8428958 [NCBI, ExPASy, EBI, Israel, Japan]
Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M., Nakanishi S.;
"Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.";
J. Biol. Chem. 268:2836-2843(1993).
[3]
 INTERACTION WITH DLG4.
PubMed=7569905 [NCBI, ExPASy, EBI, Israel, Japan]
Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H.;
"Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.";
Science 269:1737-1740(1995).
[4]
 INTERACTION WITH INADL.
DOI=10.1006/mcne.1998.0679; PubMed=9647694 [NCBI, ExPASy, EBI, Israel, Japan]
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.;
"CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.";
Mol. Cell. Neurosci. 11:161-172(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M91563; AAA41713.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D13212; BAA02499.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_036707.3; -.
UniGene Rn.9709
3D structure databases
HSSP P19491; 1FTK. [HSSP ENTRY / PDB]
SMR Q00961; 660-799.
ModBase Q00961.
Protein-protein interaction databases
IntAct Q00961; -.
PTM databases
PhosphoSite Q00961; -.
Organism-specific databases
RGD 2739; Grin2c.
Gene expression databases
ArrayExpress Q00961; -.
GermOnline ENSRNOG00000003280; Rattus norvegicus.
Ontologies
GO
GO:0030054; Cellular component: cell junction (inferred from electronic annotation from UniProtKB-KW).
GO:0045211; Cellular component: postsynaptic membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005234; Molecular function: extracellular-glutamate-gated ion channel activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006811; Biological process: ion transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR015683; Glutamate_receptor-rel.
IPR001320; Iontro_glu_rcpt.
IPR001508; NMDA_rcpt.
Graphical view of domain structure.
PANTHER PTHR18966; Glut_Rec_Related; 1.
Pfam PF00060; Lig_chan; 1.
Pfam graphical view of domain structure.
PRINTS PR00177; NMDARECEPTOR.
SMART SM00079; PBPe; 1.
SMART graphical view of domain structure.
ProtoNet Q00961.
Genome annotation databases
Ensembl ENSRNOG00000003280; Rattus norvegicus. [Contig view]
GeneID 24411; -.
KEGG rno:24411; -.
Phylogenomic databases
HOVERGEN Q00961; -.
Other
NextBio 603235; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Cell junction; Cell membrane; Glycoprotein; Ion transport; Ionic channel; Magnesium; Membrane; Postsynaptic cell membrane; Receptor; Signal; Synapse; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     19  19     Potential. 
CHAIN   20   1237  1218     Glutamate [NMDA] receptor subunit epsilon-3. PRO_0000011582
TOPO_DOM   20    553  534     Extracellular (Potential). 
TRANSMEM   554    574  21     Potential. 
TOPO_DOM   575    626  52     Cytoplasmic (Potential). 
TRANSMEM   627    647  21     Potential. 
TOPO_DOM   648    814  167     Extracellular (Potential). 
TRANSMEM   815    835  21     Potential. 
TOPO_DOM   836   1237  402     Cytoplasmic (Potential). 
MOTIF   1235   1237  3     PDZ-binding. 
SITE   612    612  1     Functional determinant of NMDA receptors (By similarity). 
CARBOHYD   70     70        N-linked (GlcNAc...) (Potential). 
CARBOHYD   337    337        N-linked (GlcNAc...) (Potential). 
CARBOHYD   438    438        N-linked (GlcNAc...) (Potential). 
CARBOHYD   539    539        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1237 AA [This is the length of the unprocessed precursor] Molecular weight: 135271 Da [This is the MW of the unprocessed precursor] CRC64: B175993804B337A4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGGALGPALL LTSLLGAWAR LGAGQGEQAV TVAVVFGSSG PLQTQARTRL TSQNFLDLPL 

        70         80         90        100        110        120 
EIQPLTVGVN NTNPSSILTQ ICGLLGAARV HGIVFEDNVD TEAVAQLLDF VSSQTHVPIL 

       130        140        150        160        170        180 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 

       190        200        210        220        230        240 
GVRAVADASY LSWRLLDVLT LELGPGGPRA RTQRLLRQVD APVLVAYCSR EEAEVLFAEA 

       250        260        270        280        290        300 
AQAGLVGPGH VWLVPNLALG STDAPPAAFP VGLISVVTES WRLSLRQKVR DGVAILALGA 

       310        320        330        340        350        360 
HSYRRQYGTL PAPAGDCRSH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVRPTMVV 

       370        380        390        400        410        420 
IALNRHRLWE MVGRWDHGVL YMKYPVWPRY STSLQPVVDS RHLTVATLEE RPFVIVESPD 

       430        440        450        460        470        480 
PGTGGCVPNT VPCRRQSNHT FSSGDLTPYT KLCCKGFCID ILKKLAKVVK FSYDLYLVTN 

       490        500        510        520        530        540 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEII DFSVPFVETG ISVMVSRSNG 

       550        560        570        580        590        600 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTKGK KPGGPSFTIG 

       610        620        630        640        650        660 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 

       670        680        690        700        710        720 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 

       730        740        750        760        770        780 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQL 

       790        800        810        820        830        840 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 

       850        860        870        880        890        900 
WKLRHSVPNS SQLDFLLAFS RGIYSCFNGV QSLPSPARPP SPDLTADSAQ ANVLKMLQAA 

       910        920        930        940        950        960 
RDMVNTADVS SSLDRATRTI ENWGNNRRVP APTASGPRSS TPGPPGQPSP SGWGPPGGGR 

       970        980        990       1000       1010       1020 
TPLARRAPQP PARPATCGPP LPDVSRPSCR HASDARWPVR VGHQGPHVSA SERRALPERS 

      1030       1040       1050       1060       1070       1080 
LLPAHCHYSS FPRAERSGRP YLPLFPEPPE PDDLPLLGPE QLARREAMLR AAWARGPRPR 

      1090       1100       1110       1120       1130       1140 
HASLPSSVAE AFTRSNPLPA RCTGHACACP CPQSRPSCRH LAQAQSLRLP SYPEACVEGV 

      1150       1160       1170       1180       1190       1200 
PAGVATWQPR QHVCLHAHTR LPFCWGTVCR HPPPCTSHSP WLIGTWEPPA HRVRTLGLGT 

      1210       1220       1230 
GYRDSGVLEE VSREACGTQG FPRSCTWRRV SSLESEV
Q00961 in FASTA format

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