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UniProtKB/Swiss-Prot entry P99140


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTLD_STAAN
Primary accession number P99140
Secondary accession number Q99SA1
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 24)
Name and origin of the protein
Protein name Mannitol-1-phosphate 5-dehydrogenase
Synonym EC 1.1.1.17
Gene name
Name: mtlD
OrderedLocusNames: SA1963
From
Staphylococcus aureus (strain N315) [TaxID: 158879] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(00)04403-2; PubMed=11418146 [NCBI, ExPASy, EBI, Israel, Japan]
Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y., Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K.;
"Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
Lancet 357:1225-1240(2001).
[2]
IDENTIFICATION BY MASS SPECTROMETRY.
DOI=10.1016/j.mimet.2004.09.017; PubMed=15590099 [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Francois P., Bento M., Deshusses J.M., Charbonnier Y., Converset V., Huyghe A., Walter N., Hoogland C., Appel R.D., Sanchez J.-C., Zimmermann-Ivol C.G., Corthals G.L., Hochstrasser D.F., Schrenzel J.;
"Correlation of proteomic and transcriptomic profiles of Staphylococcus aureus during the post-exponential phase of growth.";
J. Microbiol. Methods 60:247-257(2005).
[3]
IDENTIFICATION BY MASS SPECTROMETRY.
Vaezzadeh A.R., Deshusses J., Lescuye P., Hochstrasser D.F.;
"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315.";
Submitted (OCT-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000018; BAB43252.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C90011; C90011.
RefSeq NP_375273.1; -.
3D structure databases
ModBase P99140.
Enzyme and pathway databases
BioCyc SAUR158879:SA1963-MON; -.
2D gel databases
SWISS-2DPAGE P99140; -.
Ontologies
GO
GO:0050662; Molecular function: coenzyme binding (inferred from electronic annotation from InterPro).
GO:0008926; Molecular function: mannitol-1-phosphate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00196; -; 1.
PBIL [Tree]
InterPro IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00084; MTLDHDRGNASE.
PROSITE PS00974; MANNITOL_DHGENASE; 1.
ProtoNet P99140.
Genome annotation databases
GeneID 1124869; -.
GenomeReviews BA000018_GR; SA1963.
KEGG sau:SA1963; -.
Phylogenomic databases
HOGENOM P99140; -.
Genome annotation databases
CMR P99140; SA1963.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   368  368     Mannitol-1-phosphate 5-dehydrogenase. PRO_0000170721
NP_BIND   3    14  12     NAD (By similarity). 
Sequence information
Length: 368 AA [This is the length of the unprocessed precursor] Molecular weight: 40936 Da [This is the MW of the unprocessed precursor] CRC64: 3A6FC0F3984E46ED [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKAVHFGAGN IGRGFIGYIL ADNNVKVTFA DVNEEIINAL AHDHQYDVIL ADESKTTTRV 

        70         80         90        100        110        120 
NNVDAINSMQ PSEALKQAIL EADIITTAVG VNILPIIAKS FAPFLKEKTN HVNIVACENA 

       130        140        150        160        170        180 
IMATDTLKKA VLDITGPLGN NIHFANSAVD RIVPLQKNEN ILDVMVEPFY EWVVEKDAWY 

       190        200        210        220        230        240 
GPELNHIKYV DDLTPYIERK LLTVNTGHAY LAYAGKFAGK ATVLDAVKDS SIEAGLRRVL 

       250        260        270        280        290        300 
AETSQYITNE FDFTEAEQAG YVEKIIDRFN NSYLSDEVTR VGRGTLRKIG PKDRIIKPLT 

       310        320        330        340        350        360 
YLYNKDLERT GLLNTAALLL KYDDTADQET VEKNNYIKEH GLKAFLSEYA KVDDGLADEI 


IEAYNSLS 

P99140 in FASTA format

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