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UniProtKB/Swiss-Prot entry P97467

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AMD_MOUSE
Primary accession number P97467
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name Peptidyl-glycine alpha-amidating monooxygenase [Precursor]
Synonym PAM
Includes Peptidylglycine alpha-hydroxylating monooxygenase
     (PHM)
     (EC 1.14.17.3)
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
     (EC 4.3.2.5)
     (Peptidylamidoglycolate lyase)
     (PAL)
Gene name
Name: Pam
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Jeong J.H., Baek S.J., Park D.H.;
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
[2]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-924 AND SER-925, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U79523; AAB38364.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_038654.2; -.
UniGene Mm.441453
3D structure databases
HSSP P14925; 3PHM. [HSSP ENTRY / PDB]
SMR P97467; 44-355.
ModBase P97467.
Protein-protein interaction databases
IntAct P97467; -.
PTM databases
PhosphoSite P97467; -.
Organism-specific databases
MGI MGI:97475; Pam.
Gene expression databases
ArrayExpress P97467; -.
CleanEx MM_PAM; -.
GermOnline ENSMUSG00000026335; Mus musculus.
Ontologies
GO
GO:0005829; Cellular component: cytosol (traceable author statement from MGI).
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from MGI).
GO:0004504; Molecular function: peptidylglycine monooxygenase activity (traceable author statement from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006518; Biological process: peptide metabolic process (traceable author statement from MGI).
QuickGo view.
Family and domain databases
InterPro IPR011042; 6-blade_b-propeller_TolB-like.
IPR014783; Cu2_ascorb_mOase_C.
IPR014784; Cu2_ascorb_mOase_like_C.
IPR000323; Cu2_ascorb_mOase_N.
IPR001258; NHL_repeat.
IPR013017; NHL_repeat_subgr.
IPR000720; Pep_amidat_mOase.
Graphical view of domain structure.
Gene3D G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
G3DSA:2.60.120.230; Cu2_ascorb_mOase_core; 1.
G3DSA:2.60.120.310; Cu2_ascorb_mOase_core; 1.
Pfam PF03712; Cu2_monoox_C; 1.
PF01082; Cu2_monooxygen; 1.
PF01436; NHL; 4.
Pfam graphical view of domain structure.
PRINTS PR00790; PAMONOXGNASE.
PROSITE PS00084; CU2_MONOOXYGENASE_1; 1.
PS00085; CU2_MONOOXYGENASE_2; 1.
PS51125; NHL; 5.
PROSITE graphical view of domain structure (profiles).
BLOCKS P97467.
Genome annotation databases
Ensembl ENSMUSG00000026335; Mus musculus. [Contig view]
GeneID 18484; -.
KEGG mmu:18484; -.
Phylogenomic databases
HOGENOM P97467; -.
HOVERGEN P97467; -.
Other
SOURCE Pam; Mus musculus.
ProtoNet P97467.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cleavage on pair of basic residues; Copper; Cytoplasmic vesicle; Glycoprotein; Lyase; Membrane; Metal-binding; Monooxygenase; Multifunctional enzyme; Oxidoreductase; Phosphoprotein; Repeat; Signal; Transmembrane; Vitamin C; Zinc.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     By similarity. 
PROPEP   25    34  10     By similarity. PRO_0000006363
CHAIN   35   979  945     Peptidyl-glycine alpha-amidating monooxygenase. PRO_0000006364
TOPO_DOM   35   869  835     Intragranular (Potential). 
TRANSMEM   870   893  24     Potential. 
TOPO_DOM   894   979  86     Cytoplasmic (Potential). 
REPEAT   501   544  44     NHL 1. 
REPEAT   570   611  42     NHL 2. 
REPEAT   620   665  46     NHL 3. 
REPEAT   673   717  45     NHL 4. 
REPEAT   769   812  44     NHL 5. 
REGION   1   497  497     Peptidylglycine alpha-hydroxylating monooxygenase (By similarity). 
REGION   498   823  326     Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (By similarity). 
REGION   931   948  18     Interaction with RASSF9 (By similarity). 
METAL   106   106        Copper A (By similarity). 
METAL   107   107        Copper A (By similarity). 
METAL   171   171        Copper A (By similarity). 
METAL   241   241        Copper B (By similarity). 
METAL   243   243        Copper B (By similarity). 
METAL   313   313        Copper B (By similarity). 
MOD_RES   924   924        Phosphoserine. 
MOD_RES   925   925        Phosphoserine. 
MOD_RES   962   962        Phosphoserine (By similarity). 
MOD_RES   964   964        Phosphoserine (By similarity). 
CARBOHYD   765   765        N-linked (GlcNAc...) (Potential). 
DISULFID   46   185        By similarity. 
DISULFID   80   125        By similarity. 
DISULFID   113   130        By similarity. 
DISULFID   226   333        By similarity. 
DISULFID   292   314        By similarity. 
DISULFID   634   655        By similarity. 
DISULFID   702   713        By similarity. 
Sequence information
Length: 979 AA [This is the length of the unprocessed precursor] Molecular weight: 109048 Da [This is the MW of the unprocessed precursor] CRC64: 1F5BED76567A741A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGRARSRLL LLLGLLALQS SCLAFRSPLS VFKRFKETTR SFSNECLGTT RPITPIDSSD 

        70         80         90        100        110        120 
FTLDIRMPGV TPKESDTYFC MSMRLPVDEE AFVIDFKPRA SMDTVHHMLL FGCNMPSSTG 

       130        140        150        160        170        180 
SYWFCDEGTC TDKANILYAW ARNAPPTRLP KGVGFRVGGE TGSKYFVLQV HYGDISAFRD 

       190        200        210        220        230        240 
NHKDCSGVSL HLTRVPQPLI AGMYLMMSVN TVIPPGEKVV NSDISCHYKM YPMHVFAYRV 

       250        260        270        280        290        300 
HTHHLGKVVS GYRVRNGQWT LIGRQSPQLP QAFYPVEHPV DVAFGDILAA RCVFTGEGRT 

       310        320        330        340        350        360 
EATHIGGTSS DEMCNLYIMY YMEAKHAVSF MTCTQNVAPD MFRTIPEEAN IPIPVKSDMV 

       370        380        390        400        410        420 
MIHGHHKETE NKEKSALIQQ PKQGEEEAFE QGDFYSLLSK LLGEREDVVH VHKYNPTEKT 

       430        440        450        460        470        480 
ESGSDLVAEI ANVVQKKDLG RSDAREGAEH EEGGNAILVR DRIHKFHRLE STLRPAESRA 

       490        500        510        520        530        540 
LSFQQPGEGP WEPELAGDFH VEEALEWPGV YLLPGQVSGV ALDSKNNLVI FHRGDHVWDG 

       550        560        570        580        590        600 
NSFDSKFVYQ QRGLGPIEED TILVIDPNKA EILQSSGKNL FYLPHGLSID TDGNYWVTDV 

       610        620        630        640        650        660 
ALHQVFKLEP RSKEGPLLVL GRSMQPGSDQ NHFCQPTDVA VEPSTGAVFV SDGYCNSRIV 

       670        680        690        700        710        720 
QFSPSGKFIT QWGEESSGSS PKPGQFSVPH SLALVPHLNQ LCVADRENGR IQCFKTDTKE 

       730        740        750        760        770        780 
FVREIKHASF GRNVFAISYI PGFLFAVNGK PYFGDQEPVQ GFVMNFSSGE IIDVFKPVRK 

       790        800        810        820        830        840 
HFDMPHDIVA SEDGTVYIGD AHTNTVWKFT LTESRLEVEH RSVKKAGIEV PEIKEAEAVV 

       850        860        870        880        890        900 
EPKVKNKPTS SELQKMQEKK KLIKDPGSGV PVVLITTLLV IPVVVLLAIA MFIRWKKSRA 

       910        920        930        940        950        960 
FGDHDRKLES SSGRVLGRLR GKGSSGLNLG NFFASRKGYS RKGFDRVSTE GSDQEKDEDD 

       970 
GSESEEEYSR PLPTPAPSS
P97467 in FASTA format

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