ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P80046

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name IDH_SYNY3
Primary accession number P80046
Secondary accession number P72820
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 60)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: slr1289
From
Synechocystis sp. (strain PCC 6803) [TaxID: 1148] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8763933 [NCBI, ExPASy, EBI, Israel, Japan]
Muro-Pastor M.I., Reyes J.C., Florencio F.J.;
"The NADP+-isocitrate dehydrogenase gene (icd) is nitrogen regulated in cyanobacteria.";
J. Bacteriol. 178:4070-4076(1996).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/3.3.109; PubMed=8905231 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.";
DNA Res. 3:109-136(1996).
[3]
 PROTEIN SEQUENCE OF 1-20.
PubMed=1730247 [NCBI, ExPASy, EBI, Israel, Japan]
Muro-Pastor M.I., Florencio F.J.;
"Purification and properties of NADP-isocitrate dehydrogenase from the unicellular cyanobacterium Synechocystis sp. PCC 6803.";
Eur. J. Biochem. 203:99-105(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X83563; CAA58549.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000022; BAA16835.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S74684; S74684.
RefSeq NP_440155.1; -.
3D structure databases
HSSP P08200; 1PB1. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase P80046.
Protein-protein interaction databases
IntAct P80046; -.
Enzyme and pathway databases
BioCyc SSP1148:SLR1289-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006097; Biological process: glyoxylate cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P80046.
ProtoNet P80046.
Genome annotation databases
GeneID 953454; -.
GenomeReviews BA000022_GR; slr1289.
KEGG syn:slr1289; -.
Phylogenomic databases
HOGENOM P80046; -.
Genome annotation databases
CMR P80046; slr1289.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Direct protein sequencing; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   475  475     Isocitrate dehydrogenase [NADP]. PRO_0000083570
NP_BIND   394   400  7     NADP (By similarity). 
METAL   362   362        Magnesium or manganese (By similarity). 
BINDING   104   104        NADP (By similarity). 
BINDING   113   113        Substrate (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   129   129        Substrate (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   407   407        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   446   446        NADP (By similarity). 
BINDING   450   450        NADP (By similarity). 
SITE   160   160  1     Critical for catalysis (By similarity). 
SITE   237   237  1     Critical for catalysis (By similarity). 
MOD_RES   113   113        Phosphoserine (By similarity). 
CONFLICT   60    62        REE -> ERK (in Ref. 2; BAA16835). 
CONFLICT   83    84        IF -> YL (in Ref. 2; BAA16835). 
CONFLICT   223   223        K -> L (in Ref. 2; BAA16835). 
CONFLICT   247   247        P -> A (in Ref. 2; BAA16835). 
CONFLICT   273   273        C -> L (in Ref. 2; BAA16835). 
Sequence information
Length: 475 AA [This is the length of the unprocessed precursor] Molecular weight: 52275 Da [This is the MW of the unprocessed precursor] CRC64: 6F3254A8BBA75F92 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYEKLQPPSV GSKITFVAGK PVVPNDPIIP YIRGDGTGVD IWPATELVIN AAIAKAYGGR 

        70         80         90        100        110        120 
EEINWFKVYA GDEACELYGT YQIFPEDTLT AIKEYGVAIK GPLTTPVGGG IRSLNVALRQ 

       130        140        150        160        170        180 
IFDLYTCVRP CRYYPGTPSP HKTPEKLDII VYRENTEDIY LGIEWAEGTE GAKKLIAYLN 

       190        200        210        220        230        240 
DELIPTTPAL GKKQIRLDSG IGIKPISKTG SQRLVRRAIL HAKRLPKAKQ MVTLVHKGNI 

       250        260        270        280        290        300 
MKFTEGPFRD WGYELATTEF RAECVTERES WICGNKESNP DLTIEANAHM IDPGYDTLTE 

       310        320        330        340        350        360 
EKQAVIKQEV EQVLNSIWES HGNGQWKEKV MVNDRIADSI FQQIQTRPDE YSILATMNLN 

       370        380        390        400        410        420 
GDYLSDAAAA VVGGLGMGPG ANIGDSAAIF EATHGTAPKH AGLDRINPGS VILSGVMMLE 

       430        440        450        460        470 
FMGWQEAADL IKKGIGAAIA NREVTYDLAR LMEPKVDKPL KCSEFAQAIV SHFDD
P80046 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!