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- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
- COFACTOR: Heme group (By similarity).
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
- INDUCTION: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
- SIMILARITY: Belongs to the cytochrome P450 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 327 AA [This is the length of the partial sequence of the unprocessed precursor] |
Molecular weight: 37458 Da [This is the MW of the partial sequence of the unprocessed precursor] |
CRC64: 0EA0CA0E1B9B94D9 [This is a checksum on the sequence] |
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10 20 30 40 50 60
CDPTFILDCA PCNVICSIIF QNRFDYTDQD FLTLLEKFHE NLNILSSPWI QVCNNFPALI
70 80 90 100 110 120
DYSPGIHNKL LKNIAYLKSY VLKKVKEHQE SLDINNPRDF IDCFLIKMEQ EKHNQQSEYT
130 140 150 160 170 180
IENLIATVSD MFSAGTETTS TTMRYGLLLL LKHPEVTAKV QEEIDRVIGR HRSACMQDRS
190 200 210 220 230 240
HMPYTDAVVH EIQRYIDLVP TNLPHAVTCD IKFRNYLIPK GTTILTSLTS VLYDCKAFPN
250 260 270 280 290 300
PEVFDPGHFL DESGNFKKSD YFMPFSTGKR ICVGEGLARM ELFLFLTTIL QKFNLKSVVD
310 320
PKDIDTTPVA NGFASVPPFY QICFIPL
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P79402 in FASTA format |
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