[1]	PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY. TISSUE=Venom; Lampe R.A.; "Analgesic peptides from venom of Grammostola spatulata and use thereof."; Patent number US5877026, 02-MAR-1999.
[2]	PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY. TISSUE=Venom; Lampe R.A.; "Antiarrhythmic peptide from venom of spider Grammostola spatulata."; Patent number US5968838, 19-OCT-1999.

Comments

FUNCTION: Blocks mechanosensitive ion channels and the hypotonic cell swelling induced calcium increase associated with the activation of such channels. It can thus be useful in treating cardiac ventricular disturbances. Also induces analgesia in mammals. This analgesia is probably mediated by a non-opioid receptor related mechanism.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
DOMAIN: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin (By similarity).
MASS SPECTROMETRY: Mass=3979.9; Method=Electrospray; Range=1-31; Source=Ref.1, Ref.2;.
SIMILARITY: Belongs to the phrixotoxin family.

Copyright

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Cross-references

3D structure databases
ModBase	P61409.
Family and domain databases
BLOCKS	P61409.
Other
ProtoNet	P61409.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Knottin; Secreted; Toxin.

Features

Feature table viewer

Sequence information

Length: 31 AA [This is the length of the unprocessed precursor]

Molecular weight: 3986 Da [This is the MW of the unprocessed precursor]

CRC64: BF03EB84DE1AAC1B [This is a checksum on the sequence]

        10         20         30 
YCQKWMWTCD EERKCCEGLV CRLWCKKKIE W

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools