[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=8654111 [NCBI, ExPASy, EBI, Israel, Japan] Yang D.-I., Louis C.F.; "Molecular cloning of sheep connexin49 and its identity with MP70."; Curr. Eye Res. 15:307-314(1996).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Yang D.-I., Louis C.F.; Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
[3]	PROTEIN SEQUENCE OF 2-21. TISSUE=Lens; DOI=10.1038/331721a0; PubMed=2830542 [NCBI, ExPASy, EBI, Israel, Japan] Kistler J., Christie D., Bullivant S.; "Homologies between gap junction proteins in lens, heart and liver."; Nature 331:721-723(1988).

Comments

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
SUBUNIT: A connexon is composed of a hexamer of connexins.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
TISSUE SPECIFICITY: Eye lens.
SIMILARITY: Belongs to the connexin family. Alpha-type (group II) subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF177913; AAF01367.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P55917.

Family and domain databases

InterPro

IPR000500; Connexin.
IPR013125; Connexin50_C.
IPR013092; Connexin_N.
Graphical view of domain structure.

PANTHER

PTHR11984; Connexin; 1.

Pfam

PF00029; Connexin; 1.
PF03509; Connexin50; 1.
Pfam graphical view of domain structure.

SMART

SM00037; CNX; 1.
SMART graphical view of domain structure.

PROSITE

PS00407; CONNEXINS_1; 1.
PS00408; CONNEXINS_2; 1.

BLOCKS

P55917.

Phylogenomic databases

HOVERGEN

P55917; -.

Other

ProtoNet

P55917.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Direct protein sequencing; Gap junction; Membrane; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 440`	`439`	`Gap junction alpha-8 protein.`	`PRO_0000057832`
`TOPO_DOM`	`2 23`	`22`	`Cytoplasmic (Potential).`
`TRANSMEM`	`24 46`	`23`	`Potential.`
`TOPO_DOM`	`47 74`	`28`	`Extracellular (Potential).`
`TRANSMEM`	`75 97`	`23`	`Potential.`
`TOPO_DOM`	`98 157`	`60`	`Cytoplasmic (Potential).`
`TRANSMEM`	`158 180`	`23`	`Potential.`
`TOPO_DOM`	`181 209`	`29`	`Extracellular (Potential).`
`TRANSMEM`	`210 229`	`20`	`Potential.`
`TOPO_DOM`	`230 440`	`211`	`Cytoplasmic (Potential).`
`VARIANT`	`9 9`	`1`	`N -> R.`
`VARIANT`	`10 10`	`1`	`I -> L.`
`VARIANT`	`14 14`	`1`	`V -> A.`
`CONFLICT`	`13 13`		`E -> N (in Ref. 3; AA sequence).`
`CONFLICT`	`15 15`		`N -> Q (in Ref. 3; AA sequence).`
`CONFLICT`	`42 42`		`E -> D (in Ref. 2; AAF01367).`

Sequence information

Length: 440 AA [This is the length of the unprocessed precursor]

Molecular weight: 49160 Da [This is the MW of the unprocessed precursor]

CRC64: BE6E478B98D83891 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS DFVCNTQQPG 

        70         80         90        100        110        120 
CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYVGHAVHHV RMEEKRKERE AEELSQQSPG 

       130        140        150        160        170        180 
NGGERAPLAA DQGSVKKSSS SSKGTKKFRL EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY 

       190        200        210        220        230        240 
GFRILPLYRC SRWPCPNVVD CFVSRPTEKT IFILFMLSVA SVSLFLNILE MSHLGLKKIR 

       250        260        270        280        290        300 
SAFKRPVEQP LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVEASPLS 

       310        320        330        340        350        360 
AKPFSQFEEK VGPGPLGDLS RAYQETLPSY AQVGAQEGVE EEQPIEAAAE PEVGDKSQEA 

       370        380        390        400        410        420 
ERVSTEGEET LAVLEEEKVE PPEVEKEAEK EETPPEKVSK QELTPEKAPS LCAELPGEDT 

       430        440 
RPLSRLSKAS SRARSDDLTV

P55917 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools