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UniProtKB/Swiss-Prot entry P52713

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_CAEEL
Primary accession number P52713
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 67)
Name and origin of the protein
Protein name Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Gene name
Name: alh-8
ORFNames: F13D12.4
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z49127; CAA88946.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T20828; T20828.
RefSeq NP_001022078.1; -.
UniGene Cel.17786
3D structure databases
HSSP Q28399; 1O9J. [HSSP ENTRY / PDB]
ModBase P52713.
Protein-protein interaction databases
DIP DIP:25038N; -.
IntAct P52713; 1.
Organism-specific databases
WormBase WBGene00000114; alh-8.
WormPep F13D12.4; CE02183. [WormPep / WorfDB]
Gene expression databases
ArrayExpress P52713; -.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0000062; Molecular function: acyl-CoA binding (inferred from sequence or structural similarity from UniProtKB).
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019859; Biological process: thymine metabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006573; Biological process: valine metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
Genome annotation databases
Ensembl F13D12.4; Caenorhabditis elegans. [Contig view]
GeneID 174800; -.
KEGG cel:F13D12.4; -.
Other
NextBio 885562; -.
ProtoNet P52713.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    22  22     Mitochondrion (By similarity). 
CHAIN   23   523  501     Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000007191
NP_BIND   199   203  5     NAD (Potential). 
NP_BIND   251   256  6     NAD (Potential). 
ACT_SITE   307   307        Nucleophile (By similarity). 
BINDING   407   407        NAD (Potential). 
Sequence information
Length: 523 AA [This is the length of the unprocessed precursor] Molecular weight: 56462 Da [This is the MW of the unprocessed precursor] CRC64: 2871499FE3267A29 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLSRLARVQP KCQQLAHFST SKSAAAAPTV KLWIDGQAVE SKTTDFVELT NPATNEVIAM 

        70         80         90        100        110        120 
VPNATQAEMQ AAVDSAKNAF NTWKNTSPLT RQQCMFKLQA LIKRDMKKLA ESITIEQGKT 

       130        140        150        160        170        180 
LPDAEGDVSR GLQVVEHACS VPSLMMGETL PNVSRDMDTH SYRIPLGVTA GICPFNFPAM 

       190        200        210        220        230        240 
IPLWMFPVAL ATGNTMVIKP SEQDPGAAQL LVELAKEAGV PDGCVNIIHG QHSAVNFICD 

       250        260        270        280        290        300 
NPDIKAISFV GGDAAGKHIY ERGAKNGKRV QSNMGAKNHG VIMADANKEQ TLNQLTAAAF 

       310        320        330        340        350        360 
GAAGQRCMAL TTAVLVGEAR AWLPELVEKA KNLKVNAGWK PDTDIGPLIS KQSKARVLRL 

       370        380        390        400        410        420 
IESAKKEGAQ VPLDGSNITV PGFENGNFVG PTILAGVKPN MTCYREEIFG PVLVVMEAEN 

       430        440        450        460        470        480 
LNEAIEIINN NPYGNGTAIF TSNGATARKF TNEVDVGQIG INVPIPVPLP MFSFTGSRGS 

       490        500        510        520 
FLGDLNFYGK AGIQFYTQWK TVTQYWNESL TELKPQMSFP QLK
P52713 in FASTA format

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