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UniProtKB/Swiss-Prot entry P44801

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHAS_HAEIN
Primary accession number P44801
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 65)
Name and origin of the protein
Protein name Aspartate-semialdehyde dehydrogenase
Synonyms ASA dehydrogenase
ASADH
EC 1.2.1.11
Gene name
Name: asd
OrderedLocusNames: HI0646
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC22306.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B64084; B64084.
RefSeq NP_438806.1; -.
3D structure databases
PDB
1NWC; X-ray; 2.04 A; A/B=1-371.[ExPASy / RCSB / EBI]
1NWH; X-ray; 2.00 A; A/B=1-371.[ExPASy / RCSB / EBI]
1NX6; X-ray; 2.15 A; A=1-371.[ExPASy / RCSB / EBI]
1OZA; X-ray; 2.06 A; A=1-371.[ExPASy / RCSB / EBI]
1PQP; X-ray; 2.06 A; A=1-371.[ExPASy / RCSB / EBI]
1PQU; X-ray; 1.92 A; A/B/C/D=1-371.[ExPASy / RCSB / EBI]
1PR3; X-ray; 2.15 A; A=1-371.[ExPASy / RCSB / EBI]
1PS8; X-ray; 2.40 A; A=1-371.[ExPASy / RCSB / EBI]
1PU2; X-ray; 2.06 A; A=1-371.[ExPASy / RCSB / EBI]
1Q2X; X-ray; 2.05 A; A/B=1-371.[ExPASy / RCSB / EBI]
1TA4; X-ray; 2.28 A; A=1-371.[ExPASy / RCSB / EBI]
1TB4; X-ray; 2.15 A; A=1-371.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1NWC; -.
1NWH; -.
1NX6; -.
1OZA; -.
1PQP; -.
1PQU; -.
1PR3; -.
1PS8; -.
1PU2; -.
1Q2X; -.
1TA4; -.
1TB4; -.
ModBase P44801.
Enzyme and pathway databases
BioCyc HINF71421:HI_0646-MON; -.
Ontologies
GO
GO:0019877; Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000319; Asp-semialdehyde_DHase_CS.
IPR011534; Asp_ADH_proteob.
IPR012080; Asp_semialdehyde_DHase.
IPR016040; NAD(P)-bd.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000148; ASA_dh; 1.
TIGRFAMs TIGR01745; asd_gamma; 1.
PROSITE PS01103; ASD; 1.
BLOCKS P44801.
ProtoNet P44801.
Genome annotation databases
GeneID 949960; -.
GenomeReviews L42023_GR; HI0646.
KEGG hin:HI0646; -.
NMPDR fig|71421.1.peg.616; -.
TIGR HI0646; -.
Phylogenomic databases
HOGENOM P44801; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   371  371     Aspartate-semialdehyde dehydrogenase. PRO_0000141375
ACT_SITE   136   136        Acyl-thioester intermediate (By similarity). 
STRAND   3     8  6      
HELIX   12    23  12      
HELIX   26    29  4      
STRAND   30    37  8      
HELIX   61    64  4      
STRAND   68    72  5      
HELIX   76    88  13      
STRAND   93   100  8      
TURN   101   104  4      
STRAND   108   111  4      
HELIX   113   126  14      
STRAND   130   133  4      
HELIX   136   150  15      
STRAND   154   163  10      
HELIX   165   167  3      
HELIX   170   185  16      
HELIX   188   192  5      
HELIX   198   210  13      
TURN   217   219  3      
STRAND   225   229  5      
TURN   236   238  3      
HELIX   242   255  14      
STRAND   264   272  9      
STRAND   274   287  14      
HELIX   291   300  10      
STRAND   303   308  6      
HELIX   312   318  7      
HELIX   321   324  4      
STRAND   330   338  9      
STRAND   341   352  12      
TURN   353   358  6      
HELIX   359   369  11      
Sequence information
Length: 371 AA [This is the length of the unprocessed precursor] Molecular weight: 40539 Da [This is the MW of the unprocessed precursor] CRC64: E44CE5B90F2AF041 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKNVGFIGWR GMVGSVLMDR MSQENDFENL NPVFFTTSQA GQKAPVFGGK DAGDLKSAFD 

        70         80         90        100        110        120 
IEELKKLDII VTCQGGDYTN EVYPKLKATG WDGYWVDAAS ALRMKDDAII VLDPVNQHVI 

       130        140        150        160        170        180 
SEGLKKGIKT FVGGNCTVSL MLMAIGGLFE KDLVEWISVA TYQAASGAGA KNMRELLSQM 

       190        200        210        220        230        240 
GLLEQAVSSE LKDPASSILD IERKVTAKMR ADNFPTDNFG AALGGSLIPW IDKLLPETGQ 

       250        260        270        280        290        300 
TKEEWKGYAE TNKILGLSDN PIPVDGLCVR IGALRCHSQA FTIKLKKDLP LEEIEQIIAS 

       310        320        330        340        350        360 
HNEWVKVIPN DKEITLRELT PAKVTGTLSV PVGRLRKLAM GPEYLAAFTV GDQLLWGAAE 

       370 
PVRRILKQLV A
P44801 in FASTA format

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