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UniProtKB/Swiss-Prot entry P35454

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NEU1_MOUSE
Primary accession number P35454
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 60)
Name and origin of the protein
Protein name Oxytocin-neurophysin 1 [Precursor]
Synonym OT-NPI
Contains Oxytocin
     (Ocytocin)
Neurophysin 1
Gene name
Name: Oxt
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0169-328X(90)90045-F; PubMed=2176709 [NCBI, ExPASy, EBI, Israel, Japan]
Hara Y., Battey J., Gainer H.;
"Structure of mouse vasopressin and oxytocin genes.";
Brain Res. Mol. Brain Res. 8:319-324(1990).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ILS, and ISS;
DOI=10.1007/s00335-001-1001-x; PubMed=11471062 [NCBI, ExPASy, EBI, Israel, Japan]
Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.;
"High-throughput sequence identification of gene coding variants within alcohol-related QTLs.";
Mamm. Genome 12:657-663(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M88355; AAC42024.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF483508; AAL90782.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF483509; AAL90783.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A43755; A43755.
RefSeq NP_035155.1; -.
UniGene Mm.16745
3D structure databases
HSSP P01175; 1L5C. [HSSP ENTRY / PDB]
SMR P35454; 32-123.
ModBase P35454.
Organism-specific databases
MGI MGI:97453; Oxt.
GeneLynx Oxt; Mus musculus.
Gene expression databases
ArrayExpress P35454; -.
CleanEx MM_OXT; -.
GermOnline ENSMUSG00000027301; Mus musculus.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000981; Neurhyp_horm.
IPR016321; Nonapeptide_hormone_prcur.
Graphical view of domain structure.
Gene3D G3DSA:2.60.9.10; Neurhyp_horm; 1.
Pfam PF00220; Hormone_4; 1.
PF00184; Hormone_5; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001815; Nonapeptide_hormone_precursor; 1.
PRINTS PR00831; NEUROPHYSIN.
ProDom PD001676; Neurhyp_horm; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00003; NH; 1.
SMART graphical view of domain structure.
PROSITE PS00264; NEUROHYPOPHYS_HORM; 1.
BLOCKS P35454.
Genome annotation databases
Ensembl ENSMUSG00000027301; Mus musculus. [Contig view]
GeneID 18429; -.
KEGG mmu:18429; -.
Phylogenomic databases
HOGENOM P35454; -.
HOVERGEN P35454; -.
Other
SOURCE Oxt; Mus musculus.
ProtoNet P35454.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Hormone; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     By similarity. 
PEPTIDE   20    28  9     Oxytocin. PRO_0000020497
CHAIN   32   125  94     Neurophysin 1. PRO_0000020498
MOD_RES   28    28        Glycine amide (By similarity). 
DISULFID   20    25        By similarity. 
DISULFID   41    85        By similarity. 
DISULFID   44    58        By similarity. 
DISULFID   52    75        By similarity. 
DISULFID   59    65        By similarity. 
DISULFID   92   104        By similarity. 
DISULFID   98   116        By similarity. 
DISULFID   105   110        By similarity. 
Sequence information
Length: 125 AA [This is the length of the unprocessed precursor] Molecular weight: 12851 Da [This is the MW of the unprocessed precursor] CRC64: 96D3135EBBA2436E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA 

        70         80         90        100        110        120 
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES 


AFSER
P35454 in FASTA format

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