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UniProtKB/Swiss-Prot entry P29057

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH1_HEVBR
Primary accession number P29057
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on December 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 63)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Synonyms HMG-CoA reductase 1
EC 1.1.1.34
Gene name
Name: HMGR1
From
Hevea brasiliensis (Para rubber tree) [TaxID: 3981] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids I; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae; Hevea.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=cv. RRIM 600;
TISSUE=Leaf;
DOI=10.1007/BF00023422; PubMed=1714317 [NCBI, ExPASy, EBI, Israel, Japan]
Chye M.L., Kush A., Tan C.T., Chua N.H.;
"Characterization of cDNA and genomic clones encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase from Hevea brasiliensis.";
Plant Mol. Biol. 16:567-577(1991).
[2]
 NUCLEOTIDE SEQUENCE.
Venkatachalam P., Priya P., Thulaseedharan A.;
"Cloning and nucleotide sequence analysis of HMGR1 gene in Hevea brasiliensis.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X54657; CAA38467.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X54659; CAA38469.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY352338; AAQ63055.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S14955; S14955.
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase P29057.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0042170; Cellular component: plastid membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004420; Molecular function: hydroxymethylglutaryl-CoA reductase (NADPH) activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0015936; Biological process: coenzyme A metabolic process (inferred from electronic annotation from InterPro).
GO:0008299; Biological process: isoprenoid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P29057.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; Mitochondrion; NADP; Oxidoreductase; Plastid; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   575  575     3-hydroxy-3-methylglutaryl-coenzyme A reductase 1. PRO_0000114440
TRANSMEM   29    49  21     Potential. 
TRANSMEM   73    93  21     Potential. 
TRANSMEM   531   551  21     Potential. 
REGION   97   160  64     Linker (By similarity). 
REGION   161   575  415     Catalytic (By similarity). 
ACT_SITE   254   254        Charge relay system (By similarity). 
ACT_SITE   386   386        Charge relay system (By similarity). 
ACT_SITE   462   462        Charge relay system (By similarity). 
ACT_SITE   560   560        Proton donor (By similarity). 
CARBOHYD   132   132        N-linked (GlcNAc...) (Potential). 
CARBOHYD   318   318        N-linked (GlcNAc...) (Potential). 
CARBOHYD   564   564        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 575 AA [This is the length of the unprocessed precursor] Molecular weight: 61695 Da [This is the MW of the unprocessed precursor] CRC64: BC0A74898B6124D5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDTTGRLHHR KHATPVEDRS PTTPKASDAL PLPLYLTNAV FFTLFFSVAY YLLHRWRDKI 

        70         80         90        100        110        120 
RNSTPLHIVT LSEIVAIVSL IASFIYLLGF FGIDFVQSFI ARASHDVWDL EDTDPNYLID 

       130        140        150        160        170        180 
EDHRLVTCPP ANISTKTTII AAPTKLPTSE PLIAPLVSEE DEMIVNSVVD GKIPSYSLES 

       190        200        210        220        230        240 
KLGDCKRAAA IRREALQRMT RRSLEGLPVE GFDYESILGQ CCEMPVGYVQ IPVGIAGPLL 

       250        260        270        280        290        300 
LNGREYSVPM ATTEGCLVAS TNRGCKAIYL SGGATSVLLK DGMTRAPVVR FASATRAAEL 

       310        320        330        340        350        360 
KFFLEDPDNF DTLAVVFNKS SRFARLQGIK CSIAGKNLYI RFSCSTGDAM GMNMVSKGVQ 

       370        380        390        400        410        420 
NVLEFLQSDF SDMDVIGISG NFCSDKKPAA VNWIEGRGKS VVCEAIIKEE VVKKVLKTNV 

       430        440        450        460        470        480 
ASLVELNMLK NLAGSAVAGA LGGFNAHAGN IVSAIFIATG QDPAQNVESS HCITMMEAVN 

       490        500        510        520        530        540 
DGKDLHISVT MPSIEVGTVG GGTQLASQSA CLNLLGVKGA NKESPGSNSR LLAAIVAGSV 

       550        560        570 
LAGELSLMSA IAAGQLVKSH MKYNRSSKDM SKAAS
P29057 in FASTA format

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