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UniProtKB/Swiss-Prot entry P23113

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LUXC_PHOLU
Primary accession number P23113
Secondary accession number Q56820
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on May 10, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 40)
Name and origin of the protein
Protein name Acyl-CoA reductase
Synonym EC 1.2.1.50
Gene name
Name: luxC
From
Photorhabdus luminescens (Xenorhabdus luminescens) [TaxID: 29488] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Photorhabdus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Hw;
PubMed=1995589 [NCBI, ExPASy, EBI, Israel, Japan]
Xi L., Cho K.W., Tu S.C.;
"Cloning and nucleotide sequences of lux genes and characterization of luciferase of Xenorhabdus luminescens from a human wound.";
J. Bacteriol. 173:1399-1405(1991).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Hw;
PubMed=1644764 [NCBI, ExPASy, EBI, Israel, Japan]
Meighen E.A., Szittner R.B.;
"Multiple repetitive elements and organization of the lux operons of luminescent terrestrial bacteria.";
J. Bacteriol. 174:5371-5381(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M62917; AAA63563.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M90092; AAD05355.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42951; A42951.
3D structure databases
ModBase P23113.
Ontologies
GO
GO:0019109; Molecular function: acyl-CoA reductase activity (inferred from electronic annotation from InterPro).
GO:0050062; Molecular function: long-chain-fatty-acyl-CoA reductase activity (inferred from electronic annotation from EC).
GO:0008218; Biological process: bioluminescence (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR008670; LuxC.
Graphical view of domain structure.
Pfam PF05893; LuxC; 1.
Pfam graphical view of domain structure.
ProtoNet P23113.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Luminescence; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   480  480     Acyl-CoA reductase. PRO_0000220199
CONFLICT   2     3        NK -> PP (in Ref. 1; AAA63563). 
CONFLICT   81    81        T -> P (in Ref. 1; AAA63563). 
CONFLICT   86    95        LKRYMGYSEE -> PKKIYGIFRR (in Ref. 1; AAA63563). 
CONFLICT   103   103        W -> R (in Ref. 1; AAA63563). 
CONFLICT   196   196        D -> V (in Ref. 1; AAA63563). 
CONFLICT   209   209        Y -> D (in Ref. 1; AAA63563). 
Sequence information
Length: 480 AA [This is the length of the unprocessed precursor] Molecular weight: 54847 Da [This is the MW of the unprocessed precursor] CRC64: 57C40EF27BB3810D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNKKISFIIN GRVEIFPESD DLVQSINFGD NSVHLPVLND SQVKNIIDYN ENNELQLHNI 

        70         80         90        100        110        120 
INFLYTVGQR WKNEEYSRRR TYIRDLKRYM GYSEEMAKLE ANWISMILCS KGGLYDLVKN 

       130        140        150        160        170        180 
ELGSRHIMDE WLPQDESYIR AFPKGKSVHL LTGNVPLSGV LSILRAILTK NQCIIKTSST 

       190        200        210        220        230        240 
DPFTANALAL SFIDVDPHHP VTRSLSVVYW QHQGDISLAK EIMQHADVVV AWGGEDAINW 

       250        260        270        280        290        300 
AVKHAPPDID VMKFGPKKSF CIIDNPVDLV SAATGAAHDV CFYDQQACFS TQNIYYMGSH 

       310        320        330        340        350        360 
YEEFKLALIE KLNLYAHILP NTKKDFDEKA AYSLVQKECL FAGLKVEVDV HQRWMVIESN 

       370        380        390        400        410        420 
AGVELNQPLG RCVYLHHVDN IEQILPYVRK NKTQTISVFP WEAALKYRDL LALKGAERIV 

       430        440        450        460        470        480 
EAGMNNIFRV GGAHDGMRPL QRLVTYISHE RPSHYTAKDV AVEIEQTRFL EEDKFLVFVP
P23113 in FASTA format

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