ID FGF6_HUMAN Reviewed; 208 AA. AC P10767; Q0VAE1; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 4. DT 25-NOV-2008, entry version 85. DE RecName: Full=Fibroblast growth factor 6; DE Short=FGF-6; DE AltName: Full=Heparin-binding growth factor 6; DE Short=HBGF-6; DE AltName: Full=HST-2; DE Flags: Precursor; GN Name=FGF6; Synonyms=HST2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=91360279; PubMed=1886714; RA Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.; RT "Putative structure of the FGF6 gene product and role of the signal RT peptide."; RL Oncogene 6:1437-1444(1991). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-36; VAL-63; RP VAL-174 AND TRP-191. RA Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., RA Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., RA Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; RT "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department RT of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 11-208. RX MEDLINE=92195660; PubMed=1549352; RA Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., RA Sato T., Onda M., Sugimura T., Terada M.; RT "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."; RL Oncogene 7:303-309(1992). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208. RX MEDLINE=89201880; PubMed=2649847; RA Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., RA Planche J., de Lapeyriere O., Birnbaum D.; RT "Characterization of the HST-related FGF.6 gene, a new member of the RT fibroblast growth factor gene family."; RL Oncogene 4:335-340(1989). CC -!- FUNCTION: Can transform NIH 3T3 cells. Exhibits strong mitogenic CC and angiogenic properties. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space. CC -!- TISSUE SPECIFICITY: Leukemia cell lines with platelet/ CC megakaryocytic differentiation potential. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X57075; CAA40358.1; -; Genomic_DNA. DR EMBL; X57075; CAA40359.1; ALT_INIT; Genomic_DNA. DR EMBL; X57075; CAA40360.1; ALT_INIT; Genomic_DNA. DR EMBL; AY581424; AAS79318.1; -; Genomic_DNA. DR EMBL; BC121097; AAI21098.1; -; mRNA. DR EMBL; BC121098; AAI21099.1; -; mRNA. DR EMBL; X63454; CAA45054.1; -; mRNA. DR EMBL; X14071; CAB37648.2; -; Genomic_DNA. DR EMBL; X14072; CAB37648.2; JOINED; Genomic_DNA. DR EMBL; X14073; CAB37648.2; JOINED; Genomic_DNA. DR PIR; S20102; S20102. DR RefSeq; NP_066276.2; -. DR UniGene; Hs.166015; -. DR HSSP; P08620; 1IJT. DR DIP; DIP:6035N; -. DR PhosphoSite; P10767; -. DR Ensembl; ENSG00000111241; Homo sapiens. DR GeneID; 2251; -. DR KEGG; hsa:2251; -. DR NMPDR; fig|9606.3.peg.6985; -. DR H-InvDB; HIX0036856; -. DR HGNC; HGNC:3684; FGF6. DR MIM; 134921; gene. DR PharmGKB; PA28123; -. DR HOGENOM; P10767; -. DR HOVERGEN; P10767; -. DR Reactome; REACT_9470; Signaling by FGFR. DR NextBio; 9113; -. DR ArrayExpress; P10767; -. DR CleanEx; HS_FGF6; -. DR GermOnline; ENSG00000111241; Homo sapiens. DR GO; GO:0005576; C:extracellular region; TAS:ProtInc. DR GO; GO:0008083; F:growth factor activity; TAS:ProtInc. DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; TAS:ProtInc. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling...; EXP:Reactome. DR InterPro; IPR002209; GF_heparin_bd. DR InterPro; IPR002348; IL1_HBGF. DR PANTHER; PTHR11486; IL1_HBGF; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR ProDom; PD000831; IL1_HBGF; 1. DR SMART; SM00442; FGF; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 2: Evidence at transcript level; KW Angiogenesis; Developmental protein; Differentiation; Glycoprotein; KW Growth factor; Mitogen; Polymorphism; Proto-oncogene; Secreted; KW Signal. FT SIGNAL 1 37 Potential. FT CHAIN 38 208 Fibroblast growth factor 6. FT /FTId=PRO_0000008961. FT CARBOHYD 45 45 N-linked (GlcNAc...) (Potential). FT DISULFID 90 157 Potential. FT VARIANT 36 36 V -> A (in dbSNP:rs11613495). FT /FTId=VAR_018882. FT VARIANT 63 63 A -> V (in dbSNP:rs17183529). FT /FTId=VAR_018883. FT VARIANT 174 174 D -> V (in dbSNP:rs7961645). FT /FTId=VAR_018884. FT VARIANT 191 191 R -> W (in dbSNP:rs17183778). FT /FTId=VAR_018885. FT CONFLICT 100 100 V -> G (in Ref. 5; CAB37648). SQ SEQUENCE 208 AA; 22905 MW; 79EF44685B324322 CRC64; MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT VTHFLPRI //