NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/16.4.1551; PubMed=3347497 [NCBI, ExPASy, EBI, Israel, Japan]
Miyamoto C.M., Graham A.F., Meighen E.A.;
"Nucleotide sequence of the LuxC gene and the upstream DNA from the bioluminescent system of Vibrio harveyi.";
Nucleic Acids Res. 16:1551-1562(1988).

Comments

FUNCTION: LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
CATALYTIC ACTIVITY: A long-chain aldehyde + CoA + NADP⁺ = a long-chain acyl-CoA + NADPH.
PATHWAY: Lipid metabolism; bioluminescent fatty acid reduction .
SIMILARITY: Belongs to the luxC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X07084; CAA30116.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X07084; CAA30117.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A28534; A28534.

3D structure databases

ModBase

P08639.

Ontologies

GO:0019109;	Molecular function: acyl-CoA reductase activity (inferred from electronic annotation from InterPro).
GO:0050062;	Molecular function: long-chain-fatty-acyl-CoA reductase activity (inferred from electronic annotation from EC).
GO:0008218;	Biological process: bioluminescence (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR008670; LuxC.
Graphical view of domain structure.

Pfam

PF05893; LuxC; 1.
Pfam graphical view of domain structure.

ProtoNet

P08639.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Luminescence; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 477`	`477`		`Acyl-CoA reductase.`	`PRO_0000220202`

Sequence information

Length: 477 AA [This is the length of the unprocessed precursor]

Molecular weight: 54840 Da [This is the MW of the unprocessed precursor]

CRC64: 86D776D3474A6918 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEKHLPLIVN GQIISTEENR FEISFEEKKV KIDSFNNLHL TQMVNHDYLN DLNINNIINF 

        70         80         90        100        110        120 
LYTTGQRWKS EEYSRRRAYI RSLITYLGYS PQMAKLEANW IAMILCSKSA LYDIIDTELG 

       130        140        150        160        170        180 
STHIQDEWLP QGECYVRAFP KGRTMHLLAG NVPLSGVTSI LRGILTRNQC IVRMSASDPF 

       190        200        210        220        230        240 
TAHALAMSFI DVDPNHPISR SISVLYWPHA SDTTLAEELL SHMDAVVAWG GRDAIDWAVK 

       250        260        270        280        290        300 
HSPSHIDVLK FGPKKSFTVL DHPADLEEAA SGVAHDICFY DQNACFSTQN IYFSGDKYEE 

       310        320        330        340        350        360 
FKLKLVEKLN LYQEVLPKSK QSFDDEALFS MTRLECQFSG LKVISEPENN WMIIESEPGV 

       370        380        390        400        410        420 
EYNHPLSRCV YVHKINKVDD VVQYIEKHQT QTISFYPWES SKKYRDAFAA KGVERIVESG 

       430        440        450        460        470 
MNNIFRAGGA HDAMRPLQRL VRFVSHERPY NFTTKDVSVE IEQTRFLEED KFLVFVP

P08639 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools