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UniProtKB/Swiss-Prot entry P06811


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LAC1_NEUCR
Primary accession number P06811
Secondary accession numbers P10574 Q7RV60
Integrated into Swiss-Prot on January 1, 1988
Sequence was last modified on November 28, 2006 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 74)
Name and origin of the protein
Protein name Laccase [Precursor]
Synonyms EC 1.10.3.2
Benzenediol:oxygen oxidoreductase
Urishiol oxidase
Diphenol oxidase
Gene name
Name: lacc
ORFNames: NCU04528
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=Oak Ridge, and TS;
PubMed=2961749 [NCBI, ExPASy, EBI, Israel, Japan]
Germann U.A., Mueller G., Hunziker P.E., Lerch K.;
"Characterization of two allelic forms of Neurospora crassa laccase. Amino- and carboxyl-terminal processing of a precursor.";
J. Biol. Chem. 263:885-896(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 379-619.
PubMed=2947240 [NCBI, ExPASy, EBI, Israel, Japan]
Germann U.A., Lerch K.;
"Isolation and partial nucleotide sequence of the laccase gene from Neurospora crassa: amino acid sequence homology of the protein to human ceruloplasmin.";
Proc. Natl. Acad. Sci. U.S.A. 83:8854-8858(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M18333; AAA33591.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18334; AAA33592.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000021; EAA27703.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M14554; AAA33590.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A28523; KSNCLO.
B28523; KSNCLT.
RefSeq XP_956939.1; -.
3D structure databases
HSSP Q9Y780; 1HFU. [HSSP ENTRY / PDB]
SMR P06811; 55-606.
ModBase P06811.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from InterPro).
GO:0008471; Molecular function: laccase activity (inferred from electronic annotation from EC).
GO:0046274; Biological process: lignin catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.420; Cupredoxin; 1.
Pfam PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.
PROSITE PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; 1.
ProtoNet P06811.
Genome annotation databases
GeneID 3873077; -.
KEGG ncr:NCU04528; -.
NMPDR fig|5141.1.peg.1814; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Copper; Direct protein sequencing; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
PROPEP   22    49  28      PRO_0000002921
CHAIN   50   606  557     Laccase. PRO_0000002922
PROPEP   607   619  13      PRO_0000002923
DOMAIN   84   207  124     Plastocyanin-like 1. 
DOMAIN   216   373  158     Plastocyanin-like 2. 
DOMAIN   431   566  136     Plastocyanin-like 3. 
METAL   144   144        Copper 1; type 2 (By similarity). 
METAL   146   146        Copper 2; type 3 (By similarity). 
METAL   189   189        Copper 2; type 3 (By similarity). 
METAL   191   191        Copper 3; type 3 (By similarity). 
METAL   477   477        Copper 4; type 1 (By similarity). 
METAL   480   480        Copper 1; type 2 (By similarity). 
METAL   482   482        Copper 3; type 3 (By similarity). 
METAL   548   548        Copper 3; type 3 (By similarity). 
METAL   549   549        Copper 4; type 1 (By similarity). 
METAL   550   550        Copper 2; type 3 (By similarity). 
METAL   554   554        Copper 4; type 1 (By similarity). 
CARBOHYD   139   139        N-linked (GlcNAc...) (Potential). 
CARBOHYD   282   282        N-linked (GlcNAc...) (Potential). 
CARBOHYD   295   295        N-linked (GlcNAc...) (Potential). 
CARBOHYD   340   340        N-linked (GlcNAc...) (Potential). 
CARBOHYD   422   422        N-linked (GlcNAc...) (Potential). 
CARBOHYD   444   444        N-linked (GlcNAc...) (Potential). 
VARIANT   17    17  1     S -> P (in strain: Oak Ridge). 
VARIANT   21    21  1     G -> A (in strain: Oak Ridge). 
VARIANT   98    98  1     I -> L (in strain: TS). 
VARIANT   114   114  1     K -> N (in strain: TS). 
VARIANT   292   292  1     S -> L (in strain: Oak Ridge). 
VARIANT   317   317  1     F -> L (in strain: TS). 
VARIANT   320   320  1     V -> I (in strain: TS). 
VARIANT   346   347  2     SK -> ND (in strain: TS). 
VARIANT   351   351  1     D -> T (in strain: TS). 
VARIANT   355   355  1     H -> K (in strain: TS). 
VARIANT   374   374  1     Q -> K (in strain: TS). 
VARIANT   379   379  1     V -> P (in strain: TS). 
VARIANT   439   439  1     L -> M (in strain: TS). 
Sequence information
Length: 619 AA [This is the length of the unprocessed precursor] Molecular weight: 68148 Da [This is the MW of the unprocessed precursor] CRC64: DD7C67B9135FC08A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKFLGIAALV AGLLAPSLVL GAPAPGTEGV NLLTPVDKRQ DSQAERYGGG GGGGCNSPTN 

        70         80         90        100        110        120 
RQCWSPGFNI NTDYELGTPN TGKTRRYKLT LTETDNWIGP DGVIKDKVMM VNDKIIGPTI 

       130        140        150        160        170        180 
QADWGDYIEI TVINKLKSNG TSIHWHGMHQ RNSNIQDGVN GVTECPIPPR GGSKVYRWRA 

       190        200        210        220        230        240 
TQYGTSWYHS HFSAQYGNGI VGPIVINGPA SANYDVDLGP FPLTDYYYDT ADRLVLLTQH 

       250        260        270        280        290        300 
AGPPPSNNVL FNGFAKHPTT GAGQYATVSL TKGKKHRLRL INTSVENHFQ LSLVNHSMTI 

       310        320        330        340        350        360 
ISADLVPVQP YKVDSLFLGV GQRYDVIIDA NQAVGNYWFN VTFGGSKLCG DSDNHYPAAI 

       370        380        390        400        410        420 
FRYQGAPKAL PTNQGVAPVD HQCLDLNDLK PVLQRSLNTN SIALNTGNTI PITLDGFVWR 

       430        440        450        460        470        480 
VNGTAININW NKPVLEYVLT GNTNYSQSDN IVQVEGVNQW KYWLIENDPD GAFSLPHPIH 

       490        500        510        520        530        540 
LHGHDFLILG RSPDVTAISQ TRYVFDPAVD MARLNGNNPT RRDTAMLPAK GWLLIAFRTD 

       550        560        570        580        590        600 
NPGSWLMHCH IAWHVSGGLS NQFLERAQDL RNSISPADKK AFNDNCDAWR AYFPDNAPFP 

       610 
KDDSGLRSGV KAREVKMKW 

P06811 in FASTA format

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