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UniProtKB/Swiss-Prot entry P06012

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ORF2A_CMVQ
Primary accession number P06012
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name RNA-directed RNA polymerase 2A
Synonyms protein 2A
EC 2.7.7.48
Gene name
Name: RNA2
ORFNames: ORF2a
From
Cucumber mosaic virus (strain Q) (CMV) [TaxID: 12310] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae; Cucumovirus.
Virus hosts Cucumis sativus (Cucumber) [TaxID: 3659]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=6547906 [NCBI, ExPASy, EBI, Israel, Japan]
Rezaian M.A., Williams R.H.V., Gordon K.H.J., Gould A.R., Symons R.H.;
"Nucleotide sequence of cucumber mosaic virus RNA 2 reveals a translation product significantly homologous to corresponding proteins of other viruses.";
Eur. J. Biochem. 143:277-284(1984).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X00985; CAA25494.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S07226; S07226.
3D structure databases
ModBase P06012.
Ontologies
GO
GO:0000166; Molecular function: nucleotide binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003968; Molecular function: RNA-directed RNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0006410; Biological process: transcription, RNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0019079; Biological process: viral genome replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001788; RNA-dep_RNA_pol_vir-typ.
IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.
Pfam PF00978; RdRP_2; 1.
Pfam graphical view of domain structure.
PROSITE PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P06012.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   839  839     RNA-directed RNA polymerase 2A. PRO_0000083280
DOMAIN   508   621  114     RdRp catalytic. 
Sequence information
Length: 839 AA [This is the length of the unprocessed precursor] Molecular weight: 94440 Da [This is the MW of the unprocessed precursor] CRC64: 42C8E0B9D56A8BD9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MISPPPTFSF ANLLNGSYGV DTPEEVERVR REQREDAEAA LRNYKPLPAV DVSESVPRDE 

        70         80         90        100        110        120 
PIVSQTVTAA PVTSVDDAFV SFGAEDYLEM SPSELLSAFE LMVKPLRVGE VLCSSFDRSL 

       130        140        150        160        170        180 
FISSVAMART LLLAPLTSTR TLKRFEDLVA AIYLKTDFFL EDDGPQTDVS QSDVPGYIFE 

       190        200        210        220        230        240 
PGQHSSGFEP PPICAKCDLI LYQCPCFDFN ALRESCAEKT FSHDYVIEGL DGVIDNATLL 

       250        260        270        280        290        300 
SNLGPFLLPV HCSYSKTEDP DFVVDPSLAR PTDRVDVHVV QAVCDTTLPT HGNYDDSFHQ 

       310        320        330        340        350        360 
VFVDSADYST DMDHVRLRQS DLVAKIPDGG HMLPVLNTGS GHQRVGTTKE VLTAIKKRNA 

       370        380        390        400        410        420 
DVPELGDSVN LSRLSKAVAE RFRLSYMNVD ALAKSNFVNV VSNFHAYMQK WPSSGLSYDD 

       430        440        450        460        470        480 
LPDLHAENLQ FYDHMIKSDV KPVVTDTLNV DRPVPATITF HKKTITSQFS PLFISLFERF 

       490        500        510        520        530        540 
QRCLRERVVL PVGKISSLEM TGFSVLNKHC LEIDLSKFDK SQGEFHLMIQ EHILNDLGCP 

       550        560        570        580        590        600 
APITKWWCDF HRFSYIKDKR AGVGMPISFQ RRTGDAFTYF GNTIVTMAEF AWCYDTDQFD 

       610        620        630        640        650        660 
RLLFSGDDSL AFSKLPPVGD PSKFTTLFNM EAKVMEPAVP YICSKFYSLM SLVTRFQSPT 

       670        680        690        700        710        720 
IREIQRLGTK KIPYSDNNDF LFAHFMSFVD RLKFMDRMSQ SCIDQLSIFF ELKYKKSGNE 

       730        740        750        760        770        780 
AALVLGAFKK YTANFNAYKE LYYSDRQQCD LVNTFCISEF RVIRRTTVKK KKNGCVDSSG 

       790        800        810        820        830 
VDRRPPLSQF AGGETSKTKV SRQKPASEGL QKSQRESAIY SETFPDVTIP RSRSRGLVS
P06012 in FASTA format

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View entry in raw text format (no links)
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