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UniProtKB/Swiss-Prot entry P05370

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_RAT
Primary accession number P05370
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 84)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: G6pdx
Synonyms: G6pd
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1093/nar/16.15.7746; PubMed=3412913 [NCBI, ExPASy, EBI, Israel, Japan]
Ho Y., Howard A.J., Crapo J.D.;
"Cloning and sequence of a cDNA encoding rat glucose-6-phosphate dehydrogenase.";
Nucleic Acids Res. 16:7746-7746(1988).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
 PROTEIN SEQUENCE OF 2-514.
STRAIN=Wistar;
TISSUE=Liver;
PubMed=2606104 [NCBI, ExPASy, EBI, Israel, Japan]
Jeffery J., Barros-Soederling J., Murray L., Wood I., Hansen R., Szepesi B., Joernvall H.;
"Glucose-6-phosphate dehydrogenase. Characteristics revealed by the rat liver enzyme structure.";
Eur. J. Biochem. 186:551-556(1989).
[4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-515.
Fritz R.S., Kletzien R.F.;
Submitted (NOV-1989) to the EMBL/GenBank/DDBJ databases.
[5]
 PROTEIN SEQUENCE OF 58-72; 176-192 AND 228-257, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Spinal cord;
Lubec G., Afjehi-Sadat L.;
Submitted (NOV-2006) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X07467; CAA30355.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC081820; AAH81820.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M26655; AAA41179.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M26653; AAA41179.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M26654; AAA41179.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S01233; S01233.
RefSeq NP_058702.1; -.
UniGene Rn.11040
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
SMR P05370; 28-515.
ModBase P05370.
Organism-specific databases
RGD 2645; G6pdx.
Gene expression databases
ArrayExpress P05370; -.
GermOnline ENSRNOG00000037254; Rattus norvegicus.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0006006; Biological process: glucose metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
ProtoNet P05370.
Genome annotation databases
Ensembl ENSRNOG00000037254; Rattus norvegicus. [Contig view]
GeneID 24377; -.
KEGG rno:24377; -.
Phylogenomic databases
HOVERGEN P05370; -.
Other
NextBio 603131; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Carbohydrate metabolism; Direct protein sequencing; Glucose metabolism; NADP; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   515  514     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068087
ACT_SITE   263   263        Proton acceptor (By similarity). 
BINDING   40    40        NADP (By similarity). 
BINDING   72    72        NADP (By similarity). 
BINDING   201   201        Substrate (By similarity). 
BINDING   205   205        Substrate (By similarity). 
BINDING   238   238        NADP (By similarity). 
BINDING   357   357        NADP (By similarity). 
BINDING   487   487        NADP (By similarity). 
MOD_RES   2     2        N-acetylalanine. 
MOD_RES   401   401        Phosphotyrosine (By similarity). 
MOD_RES   503   503        Phosphotyrosine (By similarity). 
MOD_RES   507   507        Phosphotyrosine (By similarity). 
CONFLICT   320   320        N -> D (in Ref. 3; AA sequence). 
Sequence information
Length: 515 AA [This is the length of the unprocessed precursor] Molecular weight: 59376 Da [This is the MW of the unprocessed precursor] CRC64: 8E92FFF3BF5A959B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAEQVALSRT QVCGILREEL YQGDAFHQAD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL 

        70         80         90        100        110        120 
LPEDTFIVGY ARSRLTVDDI RKQSEPFFKV TPEERPKLEE FFARNSYVAG QYDDPASYKH 

       130        140        150        160        170        180 
LNSHMNALHQ GMQANRLFYL ALPPTVYEAV TKNIQEICMS QTGWNRIIVE KPFGRDLQSS 

       190        200        210        220        230        240 
NQLSNHISSL FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP 

       250        260        270        280        290        300 
FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTD SDDVRDEKVK VLKCISEVET 

       310        320        330        340        350        360 
DNVVLGQYVG NPSGEGEATN GYLDDPTVPH GSTTATFAAA VLYVENERWD GVPFILRCGK 

       370        380        390        400        410        420 
ALNERKAEVR LQFRDVAGDI FHQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL 

       430        440        450        460        470        480 
DLTYGNRYKN VKLPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH KIDREKPQPI 

       490        500        510 
PYVYGSRGPT EADELMKRVG FQYEGTYKWV NPHKL
P05370 in FASTA format

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