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UniProtKB/Swiss-Prot entry P04798


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP1A1_HUMAN
Primary accession number P04798
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 109)
Name and origin of the protein
Protein name Cytochrome P450 1A1
Synonyms EC 1.14.14.1
CYPIA1
P450-P1
P450 form 6
P450-C
Gene name
Name: CYP1A1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/13.12.4503; PubMed=2989797 [NCBI, ExPASy, EBI, Israel, Japan]
Jaiswal A.K., Gonzales F.J., Nebert D.W.;
"Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.";
Nucleic Acids Res. 13:4503-4520(1985).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3838385 [NCBI, ExPASy, EBI, Israel, Japan]
Jaiswal A.K., Gonzalez F.J., Nebert D.W.;
"Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.";
Science 228:80-83(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=3019683 [NCBI, ExPASy, EBI, Israel, Japan]
Kawajiri K., Watanabe J., Gotoh O., Tagashira Y., Sogawa K., Fujii-Kuriyama Y.;
"Structure and drug inducibility of the human cytochrome P-450c gene.";
Eur. J. Biochem. 159:219-225(1986).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1097/00008571-200102000-00001; PubMed=11207026 [NCBI, ExPASy, EBI, Israel, Japan]
Corchero J., Pimprale S., Kimura S., Gonzalez F.J.;
"Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.";
Pharmacogenetics 11:1-6(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 282-425.
TISSUE=Brain;
DOI=10.1006/bbrc.1998.8171; PubMed=9500998 [NCBI, ExPASy, EBI, Israel, Japan]
Yun C.H., Park H.J., Kim S.J., Kim H.K.;
"Identification of cytochrome P450 1A1 in human brain.";
Biochem. Biophys. Res. Commun. 243:808-810(1998).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 295-484.
PubMed=3000715 [NCBI, ExPASy, EBI, Israel, Japan]
Quattrochi L.C., Okino S.T., Pendurthi U.R., Tukey R.H.;
"Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.";
DNA 4:395-400(1985).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[9]
VARIANT VAL-462.
PubMed=1722803 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi S., Watanabe J., Nakachi K., Kawajiri K.;
"Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.";
J. Biochem. 110:407-411(1991).
[10]
VARIANT ASN-461.
PubMed=8895751 [NCBI, ExPASy, EBI, Israel, Japan]
Cascorbi I., Brockmoller J., Roots I.;
"A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.";
Cancer Res. 56:4965-4969(1996).
[11]
VARIANT TRP-279.
DOI=10.1097/00008571-200002000-00003; PubMed=10739168 [NCBI, ExPASy, EBI, Israel, Japan]
Smart J., Daly A.K.;
"Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.";
Pharmacogenetics 10:11-24(2000).
[12]
VARIANTS ILE-331 AND SER-464.
DOI=10.1002/humu.48; PubMed=11295847 [NCBI, ExPASy, EBI, Israel, Japan]
Chevalier D., Allorge D., Lo-Guidice J.-M., Cauffiez C., Lhermitte M., Lafitte J.-J., Broly F.;
"Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.";
Hum. Mutat. 17:355-355(2001).
[13]
VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492.
DOI=10.2133/dmpk.18.218; PubMed=15618738 [NCBI, ExPASy, EBI, Israel, Japan]
Saito M., Egashira M., Kiyotani K., Fujieda M., Yamazaki H., Kiyohara C., Kunitoh H., Kamataki T.;
"Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.";
Drug Metab. Pharmacokinet. 18:218-222(2003).
[14]
VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492.
DOI=10.1517/14622416.5.7.895; PubMed=15469410 [NCBI, ExPASy, EBI, Israel, Japan]
Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.;
"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.";
Pharmacogenomics 5:895-931(2004).
[15]
VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462.
DOI=10.1002/humu.20134; PubMed=15643613 [NCBI, ExPASy, EBI, Israel, Japan]
Jiang Z., Dalton T.P., Jin L., Wang B., Tsuneoka Y., Shertzer H.G., Deka R., Nebert D.W.;
"Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.";
Hum. Mutat. 25:196-206(2005).
[16]
VARIANT [LARGE SCALE ANALYSIS] TRP-477.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X02612; CAA26458.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K03191; AAA52139.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X04300; CAA27843.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF253322; AAK25727.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC023019; AAH23019.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12079; AAA52152.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF040259; AAD10199.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A24797; O4HU6.
RefSeq NP_000490.1; -.
UniGene Hs.72912
3D structure databases
HSSP P00179; 1DT6. [HSSP ENTRY / PDB]
SMR P04798; 32-509.
ModBase P04798.
PTM databases
PhosphoSite P04798; -.
Enzyme and pathway databases
Reactome REACT_2063; Metabolism of xenobiotics.
Organism-specific databases
H-InvDB HIX0012410; -.
HGNC HGNC:2595; CYP1A1.
GenAtlas CYP1A1.
HPA CAB018654; -.
MIM 108330; gene. [NCBI / EBI]
PharmGKB PA27092; -.
GeneCards P04798.
Gene expression databases
ArrayExpress P04798; -.
CleanEx HS_CYP1A1; -.
GermOnline ENSG00000140465; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005792; Cellular component: microsome (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0019825; Molecular function: oxygen binding (traceable author statement from ProtInc).
GO:0050381; Molecular function: unspecific monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
IPR008066; Cyt_P450_E_grp-I_CYP1.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
PTHR19383:SF63; Cyt_P450_E_grp-I_CYP1; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR01683; EP450ICYP1A.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
ProtoNet P04798.
Genome annotation databases
Ensembl ENSG00000140465; Homo sapiens. [Contig view]
GeneID 1543; -.
KEGG hsa:1543; -.
Phylogenomic databases
HOGENOM P04798; -.
HOVERGEN P04798; -.
Other
DrugBank DB01169; Arsenic trioxide.
DB00865; Benzphetamine.
DB00290; Bleomycin.
DB00356; Chlorzoxazone.
DB00851; Dacarbazine.
DB00970; Dactinomycin.
DB00736; Esomeprazole.
DB00655; Estrone.
DB01095; Fluvastatin.
DB00176; Fluvoxamine.
DB01404; Ginseng.
DB00889; Granisetron.
DB01026; Ketoconazole.
DB00170; Menadione.
DB00466; Picrotoxin.
DB01087; Primaquine.
DB00908; Quinidine.
DB00468; Quinine.
DB00730; Thiabendazole.
LinkHub P04798; -.
NextBio 6387; -.
SOURCE CYP1A1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   512  512     Cytochrome P450 1A1. PRO_0000051627
METAL   457   457        Iron (heme axial ligand). 
MOD_RES   360   360        Phosphoserine. 
VARIANT   45    45  1     G -> D (in dbSNP:rs4646422 [NCBI]). VAR_023194 [3D]
VARIANT   66    66  1     M -> V (in dbSNP:rs35035798 [NCBI]). VAR_033817 [3D]
VARIANT   78    78  1     I -> T. VAR_023195 [3D]
VARIANT   93    93  1     R -> W (in dbSNP:rs2229150 [NCBI]). VAR_024706 [3D]
VARIANT   173   173  1     T -> R (in dbSNP:rs28399427 [NCBI]). VAR_024707 [3D]
VARIANT   279   279  1     R -> W (in dbSNP:rs34260157 [NCBI]). VAR_009280 [3D]
VARIANT   286   286  1     I -> T (in dbSNP:rs4987133 [NCBI]). VAR_020122 [3D]
VARIANT   331   331  1     M -> I (in allele CYP1A1*6). VAR_016937 [3D]
VARIANT   448   448  1     I -> N (in allele CYP1A1*8). VAR_016938 [3D]
VARIANT   461   461  1     T -> N (in allele CYP1A1*4; dbSNP:rs1799814 [NCBI]). VAR_008342 [3D]
VARIANT   462   462  1     I -> V (in allele CYP1A1*2B and allele CYP1A1*2C; dbSNP:rs1048943 [NCBI]). VAR_001243 [3D]
VARIANT   464   464  1     R -> C (in allele CYP1A1*9). VAR_016939 [3D]
VARIANT   464   464  1     R -> S (in allele CYP1A1*5). VAR_016940 [3D]
VARIANT   470   470  1     F -> V (in dbSNP:rs36121583 [NCBI]). VAR_033818 [3D]
VARIANT   477   477  1     R -> W (in allele CYP1A1*10). VAR_016941 [3D]
VARIANT   482   482  1     V -> M. VAR_024708 [3D]
VARIANT   492   492  1     P -> R (in allele CYP1A1*11). VAR_016942 [3D]
CONFLICT   26    26        I -> M (in Ref. 2; AAA52139). 
CONFLICT   235   235        D -> E (in Ref. 2; AAA52139). 
CONFLICT   381   381        F -> L (in Ref. 1; CAA26458). 
Sequence information
Length: 512 AA [This is the length of the unprocessed precursor] Molecular weight: 58165 Da [This is the MW of the unprocessed precursor] CRC64: 3C62366044148EFD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH 

        70         80         90        100        110        120 
LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS 

       130        140        150        160        170        180 
MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG 

       190        200        210        220        230        240 
PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL 

       250        260        270        280        290        300 
RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 

       310        320        330        340        350        360 
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS 

       370        380        390        400        410        420 
DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL 

       430        440        450        460        470        480 
WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF 

       490        500        510 
SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS 

P04798 in FASTA format

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