[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=6326097 [NCBI, ExPASy, EBI, Israel, Japan] Ivell R., Richter D.; "Structure and comparison of the oxytocin and vasopressin genes from rat."; Proc. Natl. Acad. Sci. U.S.A. 81:2006-2010(1984).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=3768139 [NCBI, ExPASy, EBI, Israel, Japan] Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.; "The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation."; Biol. Chem. Hoppe-Seyler 367:695-704(1986).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0014-5793(88)81003-2; PubMed=3203740 [NCBI, ExPASy, EBI, Israel, Japan] Mohr E., Bahnsen U., Kiessling C., Richter D.; "Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons."; FEBS Lett. 242:144-148(1988).
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Wistar; TISSUE=Liver; PubMed=1706187 [NCBI, ExPASy, EBI, Israel, Japan] Schmitz E., Mohr E., Richter D.; "Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE."; DNA Cell Biol. 10:81-91(1991).
[5]	PROTEIN SEQUENCE OF 32-125. DOI=10.1016/0006-291X(81)90493-9; PubMed=7036996 [NCBI, ExPASy, EBI, Israel, Japan] Chauvet M.-T., Chauvet J., Acher R.; "Identification of rat neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins."; Biochem. Biophys. Res. Commun. 103:595-603(1981).
[6]	PROTEIN SEQUENCE OF 32-100. DOI=10.1016/0014-5793(81)81028-9; PubMed=7238864 [NCBI, ExPASy, EBI, Israel, Japan] North W.G., Mitchell T.I.; "Evolution of neurophysin proteins: partial amino acid sequences of rat neurophysins."; FEBS Lett. 126:41-44(1981).
[7]	PROTEIN SEQUENCE OF 32-64. DOI=10.1016/0014-5793(77)80478-X; PubMed=891987 [NCBI, ExPASy, EBI, Israel, Japan] Schlesinger D.H., Pickering B.T., Watkins W.B., Peek J.C., Moore L.G., Audhya T.K., Walter R.; "A comparative study of partial neurophysin protein sequences of cod, guinea pig, rat and sheep."; FEBS Lett. 80:371-373(1977).
[8]	PROTEIN SEQUENCE OF 20-28. PubMed=5150741 [NCBI, ExPASy, EBI, Israel, Japan] Chauvet J., Chauvet M.-T., Acher R.; "Evolution of neurohypophyseal hormones: isolation of active principles from rabbits and rats."; Biochimie 53:1099-1104(1971).

Comments

FUNCTION: Neurophysin 1 specifically binds oxytocin.
FUNCTION: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
SIMILARITY: Belongs to the vasopressin/oxytocin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

K01701; AAA98733.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M25649; AAA41773.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X12792; CAA31281.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X59496; CAA42085.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A21183; NFRT1.

NP_037128.1; -.

3D structure databases

ModBase

P01179.

Organism-specific databases

RGD

3238; Oxt.

GeneLynx

Oxt; Rattus norvegicus.

Gene expression databases

ArrayExpress

P01179; -.

GermOnline

ENSRNOG00000021225; Rattus norvegicus.

Family and domain databases

InterPro

IPR000981; Neurhyp_horm.
IPR016321; Nonapeptide_hormone_prcur.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.9.10; Neurhyp_horm; 1.

Pfam

PF00220; Hormone_4; 1.
PF00184; Hormone_5; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001815; Nonapeptide_hormone_precursor; 1.

PRINTS

PR00831; NEUROPHYSIN.

ProDom

PD001676; Neurhyp_horm; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00003; NH; 1.
SMART graphical view of domain structure.

PROSITE

PS00264; NEUROHYPOPHYS_HORM; 1.

BLOCKS

P01179.

Genome annotation databases

Ensembl

ENSRNOG00000021225; Rattus norvegicus. [Contig view]

GeneID

25504; -.

KEGG

rno:25504; -.

Phylogenomic databases

HOVERGEN

P01179; -.

Other

P01179; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`
`PEPTIDE`	`20 28`	`9`	`Oxytocin.`	`PRO_0000020503`
`CHAIN`	`32 125`	`94`	`Neurophysin 1.`	`PRO_0000020504`
`MOD_RES`	`28 28`		`Glycine amide.`
`DISULFID`	`20 25`
`DISULFID`	`41 85`		`By similarity.`
`DISULFID`	`44 58`		`By similarity.`
`DISULFID`	`52 75`		`By similarity.`
`DISULFID`	`59 65`		`By similarity.`
`DISULFID`	`92 104`		`By similarity.`
`DISULFID`	`98 116`		`By similarity.`
`DISULFID`	`105 110`		`By similarity.`
`CONFLICT`	`100 100`		`T -> A (in Ref. 6; AA sequence).`
`CONFLICT`	`124 125`		`ER -> Q (in Ref. 5; AA sequence).`

Sequence information

Length: 125 AA [This is the length of the unprocessed precursor]

Molecular weight: 12823 Da [This is the MW of the unprocessed precursor]

CRC64: DC98F90BADC5551F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAALDLDMRK CLPCGPGGKG RCFGPSICCA 

        70         80         90        100        110        120 
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAT AGICCSPDGC RTDPACDPES 


AFSER

P01179 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools