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UniProtKB/Swiss-Prot entry Q07310

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NRX3A_RAT
Primary accession number Q07310
Secondary accession numbers Q07280 Q07311 Q07312 Q07313 Q07314
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 81)
Name and origin of the protein
Protein name Neurexin-3-alpha [Precursor]
Synonym Neurexin III-alpha
Gene name
Name: Nrxn3
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
STRAIN=Sprague-Dawley;
TISSUE=Brain;
PubMed=8341647 [NCBI, ExPASy, EBI, Israel, Japan]
Ushkaryov Y.A., Suedhof T.C.;
"Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.";
Proc. Natl. Acad. Sci. U.S.A. 90:6410-6414(1993).
[2]
 NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
TISSUE=Brain;
DOI=10.1016/0896-6273(95)90306-2; PubMed=7695896 [NCBI, ExPASy, EBI, Israel, Japan]
Ullrich B., Ushkaryov Y.A., Suedhof T.C.;
"Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.";
Neuron 14:497-507(1995).
[3]
 PROTEIN SEQUENCE OF N-TERMINUS, AND INTERACTION WITH NXPH1.
DOI=10.1074/jbc.273.52.34716; PubMed=9856994 [NCBI, ExPASy, EBI, Israel, Japan]
Missler M., Hammer R.E., Suedhof T.C.;
"Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.";
J. Biol. Chem. 273:34716-34723(1998).
[4]
 INTERACTION WITH CASK.
PubMed=8786425 [NCBI, ExPASy, EBI, Israel, Japan]
Hata Y., Butz S., Suedhof T.C.;
"CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.";
J. Neurosci. 16:2488-2494(1996).
[5]
 INTERACTION WITH ALPHA-DYSTROGLYCAN.
DOI=10.1083/jcb.200105003; PubMed=11470830 [NCBI, ExPASy, EBI, Israel, Japan]
Sugita S., Saito F., Tang J., Satz J., Campbell K., Suedhof T.C.;
"A stoichiometric complex of neurexins and dystroglycan in brain.";
J. Cell Biol. 154:435-445(2001).
Comments
  • FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
  • SUBUNIT: The laminin G-like domain 2 binds to NXPH1. Isoforms alpha 4B bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK.
  • SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Some isoforms seems to be secreted.
  • ALTERNATIVE PRODUCTS: 19 named isoforms [FASTA] produced by alternative splicing. There are five major alternatively spliced sites, each of which may be spliced in up to twelve different ways. Combinatorial splicing at each of these five sites may lead to the generation of at least 288 isoforms but for simplicity only individual splice events are explicitly described below. Isoforms Alpha 5A to isoform Alpha 5H lack the transmembrane domain. Experimental confirmation may be lacking for some isoforms.
    Name1
    SynonymsAlpha-5I
    Isoform IDQ07310-1
    This is the isoform sequence displayed in this entry.
    Name2
    SynonymsAlpha-1B
    Isoform IDQ07310-2
    Features which should be applied to build the isoform sequence: VSP_003524.
    Name3
    SynonymsAlpha-1C
    Isoform IDQ07310-3
    Features which should be applied to build the isoform sequence: VSP_003521.
    Name4
    SynonymsAlpha-1D
    Isoform IDQ07310-4
    Features which should be applied to build the isoform sequence: VSP_003521, VSP_003524.
    Name5
    SynonymsAlpha-1E
    Isoform IDQ07310-5
    Features which should be applied to build the isoform sequence: VSP_003523.
    Name6
    SynonymsAlpha-1F
    Isoform IDQ07310-6
    Features which should be applied to build the isoform sequence: VSP_003522.
    Name7
    SynonymsAlpha-3B
    Isoform IDQ07310-7
    Features which should be applied to build the isoform sequence: VSP_003525.
    Name8
    SynonymsAlpha-4B
    Isoform IDQ07310-8
    Features which should be applied to build the isoform sequence: VSP_003526.
    Name9
    SynonymsAlpha-5A
    Isoform IDQ07310-9
    Features which should be applied to build the isoform sequence: VSP_003528, VSP_003529.
    Name10
    SynonymsAlpha-5B
    Isoform IDQ07310-10
    Features which should be applied to build the isoform sequence: VSP_003527, VSP_003528, VSP_003529.
    Name11
    SynonymsAlpha-5C
    Isoform IDQ07310-11
    Features which should be applied to build the isoform sequence: VSP_003528, VSP_003530.
    Name12
    SynonymsAlpha-5D
    Isoform IDQ07310-12
    Features which should be applied to build the isoform sequence: VSP_003527, VSP_003528, VSP_003530.
    Name13
    SynonymsAlpha-5E
    Isoform IDQ07310-13
    Features which should be applied to build the isoform sequence: VSP_003528, VSP_003531.
    Name14
    SynonymsAlpha-5F
    Isoform IDQ07310-14
    Features which should be applied to build the isoform sequence: VSP_003527, VSP_003528, VSP_003531.
    Name15
    SynonymsAlpha-5G
    Isoform IDQ07310-15
    Features which should be applied to build the isoform sequence: VSP_003528, VSP_003532.
    Name16
    SynonymsAlpha-5H
    Isoform IDQ07310-16
    Features which should be applied to build the isoform sequence: VSP_003527, VSP_003528, VSP_003532.
    Name17
    SynonymsAlpha-5J
    Isoform IDQ07310-17
    Features which should be applied to build the isoform sequence: VSP_003527.
    Name18
    SynonymsAlpha-5K
    Isoform IDQ07310-18
    Features which should be applied to build the isoform sequence: VSP_003528.
    Name19
    SynonymsAlpha-5L
    Isoform IDQ07310-19
    Features which should be applied to build the isoform sequence: VSP_003527, VSP_003528.
  • TISSUE SPECIFICITY: Brain.
  • SIMILARITY: Belongs to the neurexin family.
  • SIMILARITY: Contains 3 EGF-like domains.
  • SIMILARITY: Contains 6 laminin G-like domains.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L14851; AAA02853.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L14851; AAA02854.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L14851; AAA02855.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L14851; AAA02856.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L14851; AAA02857.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L14851; AAA02858.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I48216; I48216.
RefSeq NP_446269.2; -.
UniGene Rn.10926
3D structure databases
HSSP Q63373; 1C4R. [HSSP ENTRY / PDB]
SMR Q07310; 258-438, 1093-1301.
ModBase Q07310.
Organism-specific databases
RGD 620212; Nrxn3.
GeneLynx Nrxn3; Rattus norvegicus.
Gene expression databases
ArrayExpress Q07310; -.
GermOnline ENSRNOG00000024722; Rattus norvegicus.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR000152; Asx_hydroxyl_S.
IPR013320; ConA_like_subgrp.
IPR006210; EGF.
IPR000742; EGF_3.
IPR006209; EGF_like.
IPR013032; EGF_like_reg_CS.
IPR001791; Laminin_G.
IPR012680; Laminin_G_2.
IPR003585; Neurexin-like.
IPR015447; NRX.
Graphical view of domain structure.
Gene3D G3DSA:2.60.120.200; ConA_like_subgrp; 6.
PANTHER PTHR10127:SF88; NRX; 1.
Pfam PF00008; EGF; 3.
PF02210; Laminin_G_2; 6.
Pfam graphical view of domain structure.
SMART SM00294; 4.1m; 1.
SM00181; EGF; 3.
SM00282; LamG; 6.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 1.
PS00022; EGF_1; FALSE_NEG.
PS01186; EGF_2; FALSE_NEG.
PS50026; EGF_3; 3.
PS50025; LAM_G_DOMAIN; 6.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q07310.
Genome annotation databases
Ensembl ENSRNOG00000024722; Rattus norvegicus. [Contig view]
GeneID 116508; -.
Phylogenomic databases
HOVERGEN Q07310; -.
Other
ProtoNet Q07310.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Calcium; Cell adhesion; Direct protein sequencing; EGF-like domain; Glycoprotein; Membrane; Metal-binding; Repeat; Secreted; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     27  27      
CHAIN   28   1578  1551     Neurexin-3-alpha. PRO_0000019500
TOPO_DOM   28   1503  1476     Extracellular (Potential). 
TRANSMEM   1504   1524  21     Potential. 
TOPO_DOM   1525   1578  54     Cytoplasmic (Potential). 
DOMAIN   28    202  175     Laminin G-like 1. 
DOMAIN   198    235  38     EGF-like 1. 
DOMAIN   260    444  185     Laminin G-like 2. 
DOMAIN   451    643  193     Laminin G-like 3. 
DOMAIN   647    684  38     EGF-like 2. 
DOMAIN   689    861  173     Laminin G-like 4. 
DOMAIN   875   1050  176     Laminin G-like 5. 
DOMAIN   1053   1090  38     EGF-like 3. 
DOMAIN   1094   1294  201     Laminin G-like 6. 
COMPBIAS   282    285  4     Poly-Ser. 
COMPBIAS   1323   1326  4     Poly-Thr. 
COMPBIAS   1329   1332  4     Poly-Thr. 
COMPBIAS   1407   1410  4     Poly-Thr. 
COMPBIAS   1422   1425  4     Poly-Ser. 
COMPBIAS   1511   1514  4     Poly-Ala. 
METAL   308    308        Calcium (By similarity). 
METAL   325    325        Calcium (via carbonyl oxygen) (By similarity). 
METAL   378    378        Calcium (via carbonyl oxygen) (By similarity). 
CARBOHYD   58     58        N-linked (GlcNAc...) (Potential). 
CARBOHYD   105    105        N-linked (GlcNAc...) (Potential). 
CARBOHYD   761    761        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1193   1193        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1291   1291        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1335   1335        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1500   1500        N-linked (GlcNAc...) (Potential). 
DISULFID   202    213        By similarity. 
DISULFID   207    222        By similarity. 
DISULFID   224    234        By similarity. 
DISULFID   408    444        By similarity. 
DISULFID   614    643        By similarity. 
DISULFID   651    662        By similarity. 
DISULFID   656    671        By similarity. 
DISULFID   673    683        By similarity. 
DISULFID   1022   1050        By similarity. 
DISULFID   1057   1068        By similarity. 
DISULFID   1062   1077        By similarity. 
DISULFID   1079   1089        By similarity. 
VAR_SEQ   237    256        Missing (in isoform 6). VSP_003522
VAR_SEQ   237    242        Missing (in isoform 3 and isoform 4). VSP_003521
VAR_SEQ   243    256        Missing (in isoform 5). VSP_003523
VAR_SEQ   253    256        Missing (in isoform 2 and isoform 4). VSP_003524
VAR_SEQ   754    763        DCIRINCNSS -> G (in isoform 7). VSP_003525
VAR_SEQ   1210   1239        Missing (in isoform 8). VSP_003526
VAR_SEQ   1369   1371        Missing (in isoform 10, isoform 12, isoform 14, isoform 16, isoform 17 and isoform 19). VSP_003527
VAR_SEQ   1372   1478        Missing (in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 18 and isoform 19). VSP_003528
VAR_SEQ   1479   1578        ANPTEPGIRRVPGASEVIRESNSTTGMVVGIVAAAALCIL ILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEK QASSKSGHKKQKNKDKEYYV -> VLERRIILNLKTNAHPKSLQSKTC (in isoform 11 and isoform 12). VSP_003530
VAR_SEQ   1479   1578        ANPTEPGIRRVPGASEVIRESNSTTGMVVGIVAAAALCIL ILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEK QASSKSGHKKQKNKDKEYYV -> DILLKSF (in isoform 13 and isoform 14). VSP_003531
VAR_SEQ   1479   1578        ANPTEPGIRRVPGASEVIRESNSTTGMVVGIVAAAALCIL ILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEK QASSKSGHKKQKNKDKEYYV -> ATTTTKKSNFQECGNSICPRAFLHNFLL (in isoform 15 and isoform 16). VSP_003532
VAR_SEQ   1479   1578        ANPTEPGIRRVPGASEVIRESNSTTGMVVGIVAAAALCIL ILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEK QASSKSGHKKQKNKDKEYYV -> ARSSNAARITPCRPYMDMATHLHIYPSHLHLLCSTLIDTP LPFPHPFFPMLPPSLALLKFMCCHPPP (in isoform 9 and isoform 10). VSP_003529
Sequence information
Length: 1578 AA [This is the length of the unprocessed precursor] Molecular weight: 173994 Da [This is the MW of the unprocessed precursor] CRC64: 936CF8529143D0C7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSFTLHSVFF TLKVSSFLGS LVGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 

        70         80         90        100        110        120 
TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETTVLS NKQVNDSSWH FLMVSRDRVR 

       130        140        150        160        170        180 
TGLVIDGEGQ SGELRAQRPY MDVVSDLFLG GGPADIRPSA LTLDGVQNMP GFKGLMLDLK 

       190        200        210        220        230        240 
YGNSEPRLLG SQSVQLEAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GTLCSEDVSQ 

       250        260        270        280        290        300 
GPGLSHLMMS EQGRSKAREE NVATFRGSEY LSYDLSQNPI QSSSSEITLS FKTWQRNGLI 

       310        320        330        340        350        360 
LHTGKSADYV NLALKDGAVS LVINLGSGAF EAIVEPVNGK FNDNAWHDVK VTRNLRQVTI 

       370        380        390        400        410        420 
SVDGILTTTG YTQEDYTMLG SDDSSYVGPS PSTADLPGSP VSNNFMGCLK EVVYKNNDIR 

       430        440        450        460        470        480 
LELSRLARIG ATKMKIYGEV VFKCENVATL DPINFETPEA YISLPKWNTK RMGSISFDFR 

       490        500        510        520        530        540 
TTEPNGLILL THGKPQERKD VRSQKNTKVD FFAVELLDGN LYLLLDMGSG TIKVKATQKK 

       550        560        570        580        590        600 
ANDGEWYHVD IQRDGRSGTI SVNSRRTPFT ASGQSEILDL EGDMYLGGLP ENRAGLILPT 

       610        620        630        640        650        660 
ELWTAMLNYG YVGCIRDLFI DGRSKNIRQL AEMQNAAGVK SSCSRMSAKQ CDSYPCKNNA 

       670        680        690        700        710        720 
VCKDGWNRFI CDCTGTGYWG RTCEREASIL SYDGSMYMKV IMPMVMHTEA EDVSFRFMSQ 

       730        740        750        760        770        780 
RAYGLLVATT SRDSADTLRL ELDGGRVKLM VNLDCIRINC NSSKGPETLY AGQKLNDNEW 

       790        800        810        820        830        840 
HTVRVVRRGK SLKLTVDDDV AEGTMVGDHT RLEFHNIETG IMTEKRYISV VPSSFIGHLQ 

       850        860        870        880        890        900 
SLMFNGLLYI DLCKNGDIDY CELKARFGLR NIIADPVTFK TKSSYLTLAT LQAYTSMHLF 

       910        920        930        940        950        960 
FQFKTTSADG FILFNSGDGN NFIAVELVKG YIHYVFDLGN GPNVIKGNSD RPLNDNQWHN 

       970        980        990       1000       1010       1020 
VVITRDNSNT HSLKVDTKVV TQVINGAKNL DLKGDLYMAG LAQGMYSNLP KLVASRDGFQ 

      1030       1040       1050       1060       1070       1080 
GCLASVDLNG RLPDLINDAL HRSGQIDRGC EGPSTTCQED SCANQGVCMQ QWEGFTCDCS 

      1090       1100       1110       1120       1130       1140 
MTSYSGNQCN DPGATYIFGK SGGLILYTWP ANDRPSTRSD RLAVGFSTTV KDGVLVRIDS 

      1150       1160       1170       1180       1190       1200 
APGLGDFLQL HIEQGKIGVV FNIGTVDISI KEERTPVNDG KYHVVRFTRN GANATLQVDN 

      1210       1220       1230       1240       1250       1260 
WPVNEHYPTG NTDNERRQMV KQKIPFKYNR PVEEWLQEKG RQLTIFNTQA QIAIGGKDKG 

      1270       1280       1290       1300       1310       1320 
RLFQGQLSGL YYDGLKVLNM AAENNPNIKI NGSVRLVGEV PSVSGTTHTT SMPPEMSTTV 

      1330       1340       1350       1360       1370       1380 
METTTTMATT TTRKNRSTAS IQPTSDDLVS SAECSSDDED FVECEPSTGR SDKSLSTSIF 

      1390       1400       1410       1420       1430       1440 
EGGYKAHAPK WESKDFRPNK VSETSRTTTT SLSPELIRFT ASSSSGMVPK LPAGKMNNRD 

      1450       1460       1470       1480       1490       1500 
LKPQPDIVLL PLPTAYELDS TKLKSPLITC PMFRNVPTAN PTEPGIRRVP GASEVIRESN 

      1510       1520       1530       1540       1550       1560 
STTGMVVGIV AAAALCILIL LYAMYKYRNR DEGSYQVDET RNYISNSAQS NGTLMKEKQA 

      1570 
SSKSGHKKQK NKDKEYYV
Q07310 in FASTA format

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